Brief reviews of recently published articles, organized by stem cell type.
From Nature News
Nature News reports that a group from University of Glasgow, UK, has created human pluripotent cells using a virus alone. These findings, from Andrew Baker and his colleague Nicole Kane, were reported at the International Society for Stem Cell Research annual meeting in San Francisco, California. Read more from Nature...
By Maria H. Ledran
Researchers, overseen by Bruce Gelb and Ihor Lemischka at the Mount Sinai School of Medicine (New York), have described the derivation of two separate induced pluripotent stem cell (iPSC) lines from LEOPARD syndrome patients. LEOPARD syndrome is a multifaceted autosomal-dominant developmental disease (closely related to Noonan syndrome), which can...
By Stuart P. Atkinson
Although induced pluripotent stem cell (iPSC) generation continues to forge ahead, the early molecular mechanisms behind the reprogramming process remain poorly understood. In an attempt to understand these mechanisms, Bhutani and colleagues utilised...
by Stuart P. Atkinson
Traditional techniques for the generation of induced pluripotent stem cells (iPSCs) require the use of integrating viral particles to deliver the required factors for efficient reprogramming. Reprogramming efficiency, however, lies in the region of only 0.02 to 1% of target cells, and this falls to much lower levels when non-integrational means of...
By Carla B. Mellough
The secret to eternal youth has been under pursuit for centuries. But now, results reported in Nature by a group at Harvard University shed new light on just how the ageing process might be co-ordinated across tissues and, astonishingly, that we may be able to reverse it (Mayack et al., 2010).
By Stuart P. Atkinson
DNA methylation is an epigenetic mechanism which allows the regulation of gene expression, genome structure and genome stability. Current dogma dictates that DNA methylation mainly occurs on cytosines at CG di-nucleotides, which are found clustered together forming dense patches within the genome. Such regions are known as CpG islands and usually...
by Lyle Armstrong
Induced pluripotent Stem Cells (iPSC) are widely believed to share many of the characteristics of Embryonic Stem Cells (ESC) and as such have been credited with the potential to revolutionise regenerative medicine. The potential benefit of iPSC exists because of their genetic similarity to the individual from whom they were derived, implying that if...
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