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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

January 6, 2011 | Pluripotent Stem Cells

By Stuart P. Atkinson

Current protocols for the differentiation of embryonic stem cells (ESC) to clinically relevant cell types are woefully inefficient with many millions or tens of millions of ESC used for each differentiation, only to yield small proportions of the desired cell type. This entails large scale culture and amplification of ESC, often over a large period of...

December 9, 2010 | Pluripotent Stem Cells

From the December Issue of Stem Cells

By Stuart P Atkinson

Modifications of histone proteins have been well studied in ESCs and iPSCs and we are beginning to understand the importance that these modifications have in relation to chromatin structure and gene regulation and indeed the enzymes which mediate these modifications. However, research into...

December 9, 2010 | Pluripotent Stem Cells

From Cell Stem Cell

A new study from the lab of Sheng Ding (The Scripps Research Institute), published recently in Cell Stem Cell, reports the reprogramming of human primary somatic cells using only OCT4 gene transduction and a combination of small molecules. Kim et alhad previously shown than one factor reprogramming is possible, but in human foetal...

November 26, 2010 | Society
By Marie McCullough
Inquirer Staff Writer

Is it legal for the federal government to fund human embryonic stem cell research?

Next month, a federal appeals court will hear...
November 26, 2010 | Pluripotent Stem Cells

by Stuart P. Atkinson

From the lab of Dan Kaufman at the Department of Medicine and Stem Cell Institute, University of Minnesota comes a report on the potential use of patient specific human induced pluripotent stem cells (hiPSCs) in the battle against HIV-1 infection. Kaufman’s lab have previously shown that embryonic stem cell (ESC) derived Natural Killer (NK) cells, a key...

November 24, 2010 | Pluripotent Stem Cells

By Stuart P. Atkinson

Little by little, the processes behind cellular reprogramming of lineage-committed cells to induced pluripotent stem cells (iPSCs) are being discovered and more detailed comparative studies between iPSC and embryonic stem cells (ESCs) are being undertaken. The similarity of these two cell types is generally viewed as being essential if hiPSCs are to be...

November 23, 2010 |

From this month’s edition of Stem Cells

By Carla Mellough

One of the limiting factors in the race to replenish ageing, damaged or dysfunctional cells by cell transplantation is the longevity of engrafted replacement cell types within host tissue. Results published in this month’s edition of Stem Cells from the laboratory of...

November 23, 2010 | Pluripotent Stem Cells

From this month’s edition of Stem Cells

By Carla Mellough

Elucidation of the best methods for somatic cell reprogramming which fully harness the stem cell-like capacity of induced pluripotent stem cells (iPSCs) is key prior to the utilisation of iPSC for regenerative medicine purposes. The translation of iPSC therapy from the bench to the...

November 12, 2010 | Hair Follicle Stem Cells

From Cancer Research

The microRNA miR-302 is implicated in the regulation of stemness and pluripotency, somatic cell reprogramming and more recently the global DNA demethylation and histone methylation which occurs during somatic cell reprogramming (see Splitting hairs: Follicking about with mir-302). Results from the same group in California now published in Cancer Research go...

November 11, 2010 | Cord Blood Stem Cells

Dr. Cinzia Rota wins Annual Young Investigator Award at International Stem Cell Symposium

Durham, NC & Seoul, Korea, November 2010 - The journal STEM CELLS has announced Dr. Cinzia Rota as the winner of the annual STEM CELLS Young Investigator Award. Co-sponsored by the International Stem Cell Symposium, the $10,000 prize is annually given to a young...