Featured Articles


Different Effects of Pro‐Inflammatory Factors and Hyperosmotic Stress on Corneal Epithelial Stem/Progenitor Cells and Wound Healing in Mice

Chronic inflammation and dry eye are two risk factors that impair the success rate of limbal stem cell transplantation. This study found that, compared with an IL‐1β‐ or TNF‐α‐induced inflammatory environment, sodium chloride‐induced hyperosmotic stress caused persistent impairment of corneal epithelial stem/progenitor cells by inducing more severe cell apoptosis, necrosis, and G2/M arrest of cell cycle and caused more serious epithelial wound healing delay. These findings provide the cellular basis for the strict control of inflammation and dry eye before clinical limbal stem cell transplantation, and the effective control of hyperosmotic stress by dry eye is crucial.


Microvesicles Secreted by Nitric Oxide‐Primed Mesenchymal Stromal Cells Boost the Engraftment Potential of Hematopoietic Stem Cells

Stem cell transplantation is the only curative therapy for several malignant and non‐malignant diseases. However, its efficacy critically depends on the quality and quantity of the hematopoietic stem cells (HSCs) present in the graft. This article reports a novel finding that mesenchymal stromal cells primed with nitric oxide secrete microvesicles that are enriched in mRNAs encoding HSC‐supportive genes. Results of this study show that HSCs briefly contacted with these primed vesicles possess significantly improved engraftment ability. Application of these vesicles as HSC‐priming agents would significantly improve the efficacy of clinical transplants. These data could have implications in other stem cell‐based therapies as well.

 

Journal Club Discussions

January 7, 2019

Researchers show how the inhibition of a DNA repair mediator may represent an exciting means to potentiate chemotherapy in colorectal cancer patients 

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Article Scans

January 21, 2019
Researchers exploring corneal epithelial stem cell therapy for vision loss highlight the deleterious effects of inflammation and dry eye to potential outcomes
January 21, 2019
Researchers describe how targeting the activity of a histone methyltransferase may lead to the development of improved therapies for common bone disorders
January 21, 2019
A new blastocyst complementation study describes the ability of wild type and gene-modified embryonic stem cells to contribute to mouse brain development