Stem cell transplantation is the only curative therapy for several malignant and non‐malignant diseases. However, its efficacy critically depends on the quality and quantity of the hematopoietic stem cells (HSCs) present in the graft. This article reports a novel finding that mesenchymal stromal cells primed with nitric oxide secrete microvesicles that are enriched in mRNAs encoding HSC‐supportive genes. Results of this study show that HSCs briefly contacted with these primed vesicles possess significantly improved engraftment ability. Application of these vesicles as HSC‐priming agents would significantly improve the efficacy of clinical transplants. These data could have implications in other stem cell‐based therapies as well.
Chronic inflammation and dry eye are two risk factors that impair the success rate of limbal stem cell transplantation. This study found that, compared with an IL‐1β‐ or TNF‐α‐induced inflammatory environment, sodium chloride‐induced hyperosmotic stress caused persistent impairment of corneal epithelial stem/progenitor cells by inducing more severe cell apoptosis, necrosis, and G2/M arrest of cell cycle and caused more serious epithelial wound healing delay. These findings provide the cellular basis for the strict control of inflammation and dry eye before clinical limbal stem cell transplantation, and the effective control of hyperosmotic stress by dry eye is crucial.
Researchers show how the inhibition of a DNA repair mediator may represent an exciting means to potentiate chemotherapy in colorectal cancer patients