Abstract Background Mesenchymal stem cells (MSCs) exhibit dual roles in tumor progression and therapy resistance. However, the blind mole-rat (BMR, Nannospalax xanthodon) exhibits extraordinary natural resistance to spontaneous and induced carcinogenesis, making its MSCs a subject of significant therapeutic interest.…
This is an Expression of Concern regarding: Russell M.L. Simpson, Xuechong Hong, Mei Mei Wong, Eirini Karamariti, Shirin Issa Bhaloo, Derek Warren, Wei Kong, Yanhua Hu, Qingbo Xu, Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage, Stem Cells,…
Abstract Ischemic stroke remains a major cause of long-term disability worldwide. Despite advances in acute reperfusion therapies, many survivors experience persistent neurological deficits due to irreversible neuronal loss and limited endogenous repair, highlighting the need for effective regenerative strategies. Mesenchymal…
Abstract Background Premature ovarian failure (POF) is a dysfunction that severely impacts women’s physiological health and reproductive function. Human umbilical cord mesenchymal stem cell (hUCMSC) transplantation offers a promising therapeutic option for restoring ovarian function. However, its efficacy and underlying…
Abstract Background The management of severe diabetic foot ulcers (DFUs) remains a major clinical challenge. Tibial cortex transverse transport (TTT) has emerged as an effective surgical intervention, but its underlying mechanism, particularly concerning stem cell mobilization and signaling pathways, is…
Abstract Background Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) enable cardiovascular disease modeling and regenerative research but exhibit substantial heterogeneity and incomplete metabolic maturation. Palmitate (PA) and oleate (OA) can promote aerobic maturation, although responses vary. Despite sex differences in…
Abstract Cancer stem cells (CSCs) constitute a rare yet highly adaptable tumor subpopulation that drives tumor initiation, intratumorally heterogeneity, metastasis, recurrence, and therapy resistance. Emerging evidence indicates that mitochondrial dynamics and mitochondrial ion signaling form an interconnected regulatory network that…
This is a correction to: Telma Roque, Céline Haton, Olivier Etienne, Alexandra Chicheportiche, Laure Rousseau, Ludovic Martin, Marc-André Mouthon, François D. Boussin; Lack of a p21waf1/cip-Dependent G1/S Checkpoint in Neural Stem and Progenitor Cells After DNA Damage In Vivo; Stem…
Abstract Background Loss-of-function mutations in the ABCA4 gene cause Stargardt disease (STGD1), the most common inherited macular dystrophy leading to progressive central vision loss. Methods Here, we generated human induced pluripotent stem cell–derived retinal organoids harboring a premature stop codon…
Abstract Organoid technology has emerged as a powerful platform for modeling human development, disease, and drug responses. Advances in stem cell biology and bioengineering have enabled the generation of increasingly sophisticated organoid systems that recapitulate key structural and cellular features…