Body: Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.
Body: Previous studies have suggested a possible link between head injury and increased rates of brain tumors but evidence has been limited and often inconclusive. A team has now identified a possible mechanism to explain this link, implicating genetic mutations acting in concert with brain tissue inflammation to change the behavior of cells, making them more likely to become cancerous. Although this study was largely carried out in mice, it suggests that it would be important to explore the relevance of these findings to human gliomas.
Body: Researchers have generated the first induced pluripotent stem cells (iPSCs) from bats, gaining valuable insights into the close relationship between bats and viruses.
Body: DNA can help to stimulate bone healing in a localized and targeted manner, for example after a complicated fracture or after severe tissue loss following surgery. Scientists have developed a new process in which they coat implant materials with a gene-activated biomaterial that induces stem cells to produce bone tissue.
Body: Young blood may be an elixir for older bodies, rejuvenating aging hearts, muscles, and brains. But how can old blood become young again? Stem cell scientists may have found a way.
Body: Researchers show that brain organoids -- clumps of lab-grown neurons -- can integrate with rat brains and respond to visual stimulation like flashing lights.
Body: A researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases. Researchers injected fractalkine into mice with chemically induced MS. They found the treatment increased the number of new oligodendrocytes -- vital brain and spinal cord cells that produce myelin in both embryonic and adult brains -- which are damaged during the MS autoimmune attack.
Body: New research challenges the prevailing hypothesis for how donor stem cell grafts cause graft-versus-host disease, or GVHD, and offers an alternative model that could guide development of novel therapies.
Body: In a new study using a rat model of Crohn's disease, a biodegradable hydrogel composite loaded with stem cells has shown significant success in treating perianal fistulas (PAF) -- one of the many complications of Crohn's disease.
Body: Researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional treatments and spurring growth.