Body: More than 40,000 allogeneic hematopoietic stem cell transplants are carried out worldwide every year, mostly for patients suffering from leukemia or other diseases of the hematopoietic system. Very often, the so-called graft-versus-host reaction occurs, an inflammatory disease that can affect different organs and is caused by an unwanted defense reaction of the donor cells and the body's own T cells. Scientists now show how these endogenous, tissue-derived T cells enter other organs, such as the intestine, via the blood and contribute to inflammation there. The study provides important approaches to better therapy in stem cell transplantation and new diagnostic options.
Body: Our DNA is very similar to that of the chimpanzee, which in evolutionary terms is our closest living relative. Stem cell researchers have now found a previously overlooked part of our DNA, so-called non-coded DNA, that appears to contribute to a difference which, despite all our similarities, may explain why our brains work differently.
Body: Vision loss can be a side effect from stroke. Neurons don't regenerate, and stem cell therapy is costly, difficult, and chancy. Researchers have figured out a way to use gene therapy to recover lost vision after a stroke in a mouse model.
Body: Stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration.
Body: Dry eye disease (DED) affects up to 50% of the U.S. population, costing the nation's health care system approximately $50 billion annually. A team recently completed a clinical trial using corneal epithelial stem cells to improve outcomes for DED patients.
Body: Researchers have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage.
Body: Researchers construct an embryo-like structure from human stem cells, resulting in a new way to study the earliest stages of development.
Body: A new study has found the antimicrobial properties of certain stem cell proteins could offer a potential treatment to reduce infection in skin wounds.
Body: A research team has shown that a protein named for the mythical land of youth in Irish folklore is effective at reversing aging in skeletal muscle cells.
Body: Epigenetic changes in old age increase risk of osteoporosis and bone fractures.