Body: A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study.
Body: Latest discovery could improve development of future stem cell therapies and cancer treatments.
Body: The team has discovered that for acute myeloid leukemia (AML) patients, there is a dopamine receptor pathway that becomes abnormally activated in the cancer stem cells. This inspired the clinical investigation of a dopamine receptor-inhibiting drug thioridazine as a new therapy for patients, and their focus on adult AML has revealed encouraging results.
Body: Researchers have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide. Findings could hold an important key to developing more effective treatments for osteoporosis and improving the lives of an aging population.
Body: A brain enzyme activates dormant neural stem cells, revealing how defects in its gene could lead to neurodevelopmental disorders.
Body: Muscle stem cells drive the tissue's growth and repair after such injuries. But growing these cells in the lab and using them to therapeutically replace damaged muscle has been frustratingly difficult. Researchers have discovered a factor that triggers these muscle stem cells to proliferate and heal. In a mouse model of severe muscle damage, injections of this naturally occurring protein led to the complete regeneration of muscle and the return of normal movement after severe muscle trauma.
Body: Scientists have recently developed ways to grow a variety of useful items in laboratories, from meat and diamonds to retinas and other organoids. A team has been working on ways to regenerate lost hair from stem cells. In an important step, a new study identifies a population of hair follicle stem cells in the skin and a recipe for normal cyclical regeneration in the lab.
Body: Scientists detail a system allowing them to sculpt, in a biocompatible material, the exact structure of the bone tissue, with features smaller than the size of a single protein -- a billion times smaller than a meter.
Body: A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a new study.
Body: Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in vivo is difficult, so the molecular mechanisms underlying the stemness of gastric tissue stem cells have remained a mystery.