Body: Researchers have shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.
Body: Researchers have designed a new bioink which allows small human-sized airways to be 3D-bioprinted with the help of patient cells for the first time. The 3D-printed constructs are biocompatible and support new blood vessel growth into the transplanted material. This is an important first step towards 3D-printing organs.
Body: New research identifies chemotherapy-resistant cancers' escape mechanism, which offers new anti-cancer treatment options.
Body: Researchers have identified a novel mechanism underlying hair thinning and loss during aging. By studying cell division of hair follicle stem cells in young and aged mice, the researchers found that young mice properly balance typical symmetric and asymmetric cell divisions to regenerate hair follicles. However, during aging, an atypical type of asymmetric cell division emerges, leading to hair loss. This study could help develop new approaches to regulate organ aging and aging-associated diseases.
Body: Researchers have discovered one of the reasons why more than 50 per cent of people with type 2 diabetes die from heart disease. And perhaps more significantly, they have found a way to treat it.
Body: Researchers describe a new technique for hematopoietic stem cell transplantation in embryos that does not require destroying host hematopoietic system.
Body: Researchers reconstructed the evolutionary history of cancer cells in two patients, tracing the timeline of the mutation that causes the disease to a cell of origin. In a 63-year-old patient, it occurred at around age 19; in a 34-year-old patient, at around age 9.
Body: Cancer stem cells that elude conventional treatments like chemotherapy drive long-term cancer growth and relapse. These cells are difficult to isolate and study because of their low abundance and similarity to other stem cells. Researchers have created a new method that can distinguish cancer stem cells, mature cancer cells and otherwise healthy stem cells based on their genetics and gene expression. The findings open new avenues for cancer research personalised medicine.
Body: Scientists have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function.
Body: Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers report.