Body: Investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.
Body: Certain stem cells have a unique ability to move between growth compartments in hair follicles, but get stuck as people age and so lose their ability to mature and maintain hair color, a new study shows.
Body: Young babies and newborn mice can naturally heal damage to the bones that form the top of the skull, but this ability is lost in adults. Researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials.
Body: Research reveals a promising stem cell approach to correct photoreceptor cell degeneration, which underlies several forms of visual decline and blindness.
Body: Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study. Investigators now report on the creation of embryo-like structures from monkey embryonic stem cells. The investigators also transferred these embryo-like structures into the uteruses of female monkeys and determined that the structures were able to implant and elicit a hormonal response similar to pregnancy.
Body: A team has induced stem cells to emulate the development of the human heart. The result is a sort of 'mini-heart' known as an organoid. It will permit the study of the earliest development phase of our heart and facilitate research on diseases.
Body: Researchers demonstrate therapeutic effects of tumor-initiating cell probe TiY after demonstrating its staining effects.
Body: Researchers have used pluripotent stem cells to make thymus organoids that support the development of patient-specific T-cells. The proof-of-concept work provides the basis for studying human thymus function, T-cell development, and transplant immunity.
Body: Scientists have discovered a mechanism that linked a leukemic mutation to varying potentials for disease development -- a discovery which could eventually lead to a way to identify patients with the mutation who are most at risk. The mutation is in a gene called TET2, which is prevalent in patients with myeloid leukemia. The scientists labeled and tracked individual blood stem cells in mice with the mutation and found that a subset of blood stem cells and their progeny -- known as clones -- made an outsized contribution to the overall population of blood and immune cells. The over-contributing clones tended to produce a lot of 'myeloid' cells including immune cells called granulocytes, which may potentially lead to myeloid leukemia.
Body: Researchers find stem cells use a surprising system for discarding misfolded proteins. This unique pathway could be the key to maintaining long-term health and preventing age-related blood and immune disorders.