Body: Targeting a key gene before birth could someday help lead to a treatment for Down syndrome by reversing abnormal embryonic brain development and improving cognitive function after birth, according to a new study.
Body: Meaningful studies are lacking for certain patient groups. Disease-specific registries could help close the data gap.
Body: Other than clinical observations, the stem cell field lacks a repeatable, time-sensitive, noninvasive tool to assess the effectiveness of transplanted cells in the targeted organ. Researchers analyzed biomarkers secreted from transplanted human stem cells in the recipient blood of a rodent model of heart attack. Analysis of the blood test showed responding cells had changed their gene expression, behavior and secretions, suggesting this liquid biopsy could provide a window into stem cell activity and effectiveness.
Body: Researchers have identified a new stem cell type that can significantly improve cardiac function.
Body: A new study challenges traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The findings may make it easier to manipulate stem cells for stem cell therapy.
Body: Scientists have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many therapies and can lead to relapses. The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.
Body: A study published in the journal Stem Cells describes a new and unexpected way to accelerate the maturation of induced pluripotent stem cells into cardiac muscle cells.
Body: Scientists have discovered how stem cells can develop resistance against viruses, a finding that could aid the development of stem cell therapies.
Body: Nerve cells derived from human stem cells often serve as the basis for research into brain diseases. However, these cells differ considerably in their quality and produce varying results. Scientists are therefore looking for simple cell models that lead to consistent results. Researchers describe a new model that consists of only one human nerve cell.
Body: Researchers have combined embryonic cells and liver cells in a new cell culture test. This combination lets them detect adverse effects that new medications may have on embryos early on in the drug development process.