Body: Stem cells hold the key to wound healing, as they develop into specialized cell types throughout the body -- including in teeth. Now an international team of researchers has found a mechanism that could offer a potential novel solution to tooth repair.
Body: The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor's root, according to a new study.
Body: The prostates of older mice contain more luminal progenitor cells -- cells capable of generating new prostate tissue -- than the prostates of younger mice, researchers have discovered.
Body: Researchers have developed a way to use immunotherapy drugs against treatment-resistant non-Hodgkin's lymphomas for the first time by combining them with stem cell transplantation, an approach that also dramatically increased the success of the drugs in melanoma and lung cancer.
Body: Around 22,000 people will be diagnosed this year in the US with acute myeloid leukemia (AML), the second most common type of leukemia diagnosed in adults and children. Researchers have discovered a key reason why this disease is so difficult to treat and therefore cure.
Body: This direct-to-consumer stem cell marketplace has come under increasing scrutiny, but relatively little is known about the clinics or how the treatments they offer align with the expertise of their practitioners. Investigators now offer a detailed characterization of nearly 170 stem cell businesses across Arizona, California, Colorado, Nevada, New Mexico, and Utah, where about one-third of US stem cell clinics are located.
Body: Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells -- fat cells, bone-making cells and cartilage-making cells. Respectively, those cells are called adipocytes, osteoblasts and chondrocytes. This non-hematopoietic cell system is distinct from another production line in the bone marrow -- the hematopoietic system -- that makes red blood cells, blood-clotting cells and cells of the immune system.
Body: Researchers have used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia.
Body: Molecular mechanics in the skin of mice are driven by polarity genes, a team reports.
Body: For the first time, researchers have studied and outlined the development of sebaceous glands in the skin. The study provides greater insight into the development and maintenance of the skin and how cancer mutations affect the behavior of stem cells.