Body: Drug resistance is a major obstacle in cancer treatment -- leading to relapse for many patients. In a new study, researchers report on a promising new strategy to overcome drug resistance in leukemia, using targeted doses of the widely-used chemotherapy drug doxorubicin.
Body: The point when human embryonic stem cells irreversibly commit to becoming specialized has been identified by researchers.
Body: A review of using stem cells to treat preeclampsia, a dangerous condition in pregnancy, indicates that mesenchymal stem/stromal cells (MSCs), or their secreted vesicles, have the potential to be used as therapies that could progress to clinical trials.
Body: Two stem cell researchers have found an abundance of abnormal stem cells in the lungs of patients who suffer from Chronic Obstructive Pulmonary Disease (COPD), a leading cause of death worldwide. The team, who used single cell cloning of lung stem cells to make their discovery, is now targeting the cells for new therapeutics.
Body: Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals' eyes.
Body: Crohn's disease is a chronic inflammatory disorder of the intestine that, in most cases, relapses episodically. As of now, there is no cure for this disease. A research group has discovered a marker at a microscopic level, which can be used to identify patients that show a high probability of suffering from an inflammation recurrence in the immediate future. With this insight, therapeutic counter-measures may be employed at an earlier stage.
Body: A drug that is well-tolerated in patients and prevents cancer coming back in mice has been identified.
Body: Scientists have identified a new control mechanism that enables stem cells to adapt their activity in emergency situations. For this purpose, the stem cells simultaneously modify the blueprints for hundreds of proteins encoded in the gene transcripts. In this way, they control the amount of protein produced and can also control the formation of certain proteinisoforms. If this mechanism is inactivated, stem cells lose their self-renewal potential and can no longer react adequately to danger signals or inflammation.
Body: Medical researchers have developed an 'in vivo priming' with heart-derived bioink. Using engineered stem cells and 3D bioprinting technology, they began developing medicines for cardiovascular diseases.
Body: Researchers have discovered a way to refine the production of retinal cells from embryonic stem cells for treating blindness in the elderly. Using the CRISPR/Cas9 gene editing, they have also managed to modify the cells so that they can hide from the immune system to prevent rejection.