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November 6, 2023
Body: A team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the prospect of injection-free treatment closer for people with diabetes.
October 31, 2023
Body: Researchers have harnessed a combination of lab-grown cells to regenerate damaged heart muscle. The study addresses major challenges of using heart muscle cells, called cardiomyocytes, grown from stem cells -- takes a crucial step toward future clinical applications.
October 17, 2023
Body: A team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, possibly leading to new therapies for heart disease and cardiac damage.
October 10, 2023
Body: Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. Guiding iPSCs toward a target cell line has garnered much attention, but the process remains challenging. Now, researchers from Japan have discovered that an anti-nucleolin DNA aptamer, iSN04, can determine a cell’s lineage during differentiation. By demonstrating the generation of cardiomyocytes from murine pluripotent stem cells, their concept shows promise as a regenerative therapy.
September 28, 2023
Body: A biobank for all, in which a person from any background could find a bone marrow donor for a stem cell transplant, is a major goal for stem cell science. While repositories of cell lines that could be a match for most patients are successfully materializing in some countries with genetically homogenous populations like Japan and the United Kingdom, how many more we need for a universal solution remains unknown. Researchers estimate at least 559 distinct cell lines would be required to cover 95% of the more diverse, and globally representative, people of Brazil.
September 27, 2023
Body: A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development.
September 27, 2023
Body: A cellular signal essential to development of the skeleton increases abnormally during aging to weaken bones.
September 27, 2023
Body: Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.
September 21, 2023
Body: Despite being an essential developmental process, the understanding of human embryonic genome activation is limited, owing to the lack of in vitro cell models and ethical concerns. To advance understanding, five independent research groups have recently developed human 8-cell-like cells (8CLCs) from pluripotent stem cells using different approaches. In a new study, researchers now compare the transcriptomic profiles of these 8CLCs and human pre-implantation embryos to facilitate the use of 8CLCs as cell models.
September 20, 2023
Body: Craniosynostosis, the premature fusion of the top of the skull in infants, is caused by an abnormal excess of a previously unknown type of bone-forming stem cell, according to a preclinical study.