Body: Scientists discovered how to soften hair follicle stem cells to enable them to grow hair again. These cells stiffen with age and produce less hair. In a study in mice, the investigators report that they can soften the stem cells by boosting the production of a tiny RNA, miR-205, that relaxes the hardness of the cells. When scientists genetically manipulated the stem cells to produce more miR-205, it promoted hair growth in young and old mice.
Body: Researchers have collaborated to refine a cell culture technology platform that grows genetically identical lung buds from human embryonic stem cells.
Body: Overall survival for patients with melanoma that has spread to the brain is only four to six months. Immunotherapies, which harness the power of the immune system to attack cancer cells, have garnered excitement in recent years for their potential to revolutionize the treatment of metastatic melanomas, but results from early clinical studies indicate that the prognosis for most patients remains poor. Now, scientists have integrated multiple therapeutic approaches to more effectively target melanoma in the brain. In preclinical studies, the scientists successfully activated immune responses in sophisticated mouse models that mimic human settings.
Body: The early stages of embryonic development contain many of life's mysteries. Unlocking these mysteries can help us better understand early development and birth defects, and help develop new regenerative medicine treatments. Researchers have now characterized a critical time in mammalian embryonic development using powerful and innovative imaging techniques.
Body: A scientific team has designed a strategy to fight obesity and diabetes in mice through ex vivo gene therapy which consists of implanting cells that have been manipulated and transformed in order to treat a disease. This is the first study to apply the ex vivo gene therapy technique to generate and implant cells that express the CPT1AM protein, an enzyme that plays a decisive role in many metabolic diseases such as obesity.
Body: Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study.
Body: The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. Currently, it is challenging for researchers to control the differentiation of stem cells in the lab (in vitro). Of particular interest are oocytes, which are female germ cells that develop into eggs. Understanding their development could have far-ranging impacts, from infertility treatment to conservation of endangered species. A new study has successfully induced meiotic (dividing) oocytes from the embryonic stem cells of cynomolgus monkeys, which share many physiological traits with humans. By establishing a culture method for inducing the differentiation of meiotic oocytes, the researchers aimed to shed light on germ cell development in both humans and other primates.
Body: Researchers have examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.
Body: Researchers discover a mechanism by which cancer cells escape the immune system.
Body: A team of researchers develops stem cell adhesive for arthritis treatment using mussel adhesion protein and hyaluronic acid.