Body: A preclinical study showed that injecting ovarian tissue-derived differentiated induced pluripotent stem cells can restore hormone production and fertility in mice with premature ovarian failure related to genetic diseases and cancer treatment.
Body: Researchers have identified a process by which enzymes can help prevent heart damage in chemotherapy patients.
Body: Gastrulation, the process where an embryo reorganizes itself from a hollow sphere into a multilayered structure, is considered a 'black box' of human development. This is because human embryos are typically not cultured for longer than 14 days because of bioethical concerns, and gastrulation occurs between 17- and 21-days post-fertilization. In addition, current stem cell models that mimic gastrulation have not been able to include the necessary extraembryonic tissues that give rise to the yolk sac and the placenta. Researchers now report a new method to develop 'peri-gastruloids,' an embryo-like structure that includes one of the supporting tissues, the yolk sac, missing from previous models.
Body: A new discovery paves the way for clinical trials that use patients' own cells to treat Parkinson's disease.
Body: The same message can be interpreted differently by different individuals -- also among cells. This is shown in a study by researchers who studied cell communication through Wnt signalling, which plays a decisive role in embryo development and cancer. Their findings are surprising in light of the prevailing conception of how Wnt signalling works.
Body: In an exciting new study adding to the global pool of knowledge about the roots of human cancers, researchers are establishing a clear link between different types of cancers and their embryonic origins. They also identify new concepts that can be considered in future drug discovery projects and used in standard chemotherapeutics in the clinic.
Body: As we age, our bodies change and degenerate over time in a process called senescence. Stem cells, which have the unique ability to change into other cell types, also experience senescence, which presents an issue when trying to maintain cell cultures for therapeutic use. The biomolecules produced by these cell cultures are important for various medicines and treatments, but once the cells enter a senescent state they stop producing them, and worse, they instead produce biomolecules antagonistic to these therapeutics. In a recently published study, researchers describe a new method for reversing senescence in stem cells through delivering antioxidants in the form of a crystal.
Body: Two to three weeks after conception, an embryo faces a critical point in its development. In the stage known as gastrulation, the transformation of embryonic cells into specialized cells begins. This initiates an explosion of cellular diversity in which the embryonic cells later become the precursors of future blood, tissue, muscle, and more types of cells, and the primitive body axes start to form. Studying this process in the human-specific context has posed significant challenges to biologists, but new research offers an unprecedented window into this point in time in human development.
Body: Scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding why and how pregnancies fail.
Body: Researchers have used an unprecedented stem cell zoo to compare six different mammalian species and their developmental time.