Body: Researchers used single-cell sequencing to identify a protein expressed uniquely by insulin-producing beta cells created from stem cells in the laboratory. By targeting the protein and adding a physical enrichment method, the purity of beta cells improved from 30 to 80%. Improved control over the beta cell production process will allow researchers to refine cell therapy for patients with type 1 diabetes.
Body: Scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny 'cargo packets' able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells. They say the human iPSCs they studied produced much more of the packets, formally known as extracellular vesicles, than other kinds of adult stem cells commonly used for this purpose in research.
Body: Neurodegenerative diseases like multiple sclerosis (MS) affect millions of people worldwide and occur when parts of the nervous system lose function over time. Researchers have discovered that a type of skin-related stem cell could be used to help regenerate myelin sheaths, a vital part of the nervous system linked to neurodegenerative disorders.
Body: How do bones heal, and how could they heal better? The answer to these questions may lie in a newly discovered population of 'messenger' cells, according to a recent study.
Body: Researchers have found a way to transform skin cells into the three major stem cell types that comprise early-stage embryos. The work (in mouse cells) has significant implications for modeling embryonic disease and placental dysfunctions, as well as paving the way to create whole embryos from skin cells.
Body: Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In a new study, scientists describe how cells 'decide' which of these two directions to take.
Body: New findings about an aggressive form of leukemia could aid the development of novel drugs to treat the condition.
Body: A simple injection that can help regrow damaged tissue has long been the dream of physicians and patients alike. A new study moves that dream closer to reality with a device that makes encapsulating cells much faster, cheaper and more effective.
Body: A subset of the stem cells in hair follicles have the potential to regenerate the coating that insulates neurons in mice, report scientists.
Body: Researchers in Japan have demonstrated preserving frozen animal cells without a cryoprotectant agent, relying instead on ultrarapid cooling.