Body: A new study challenges traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The findings may make it easier to manipulate stem cells for stem cell therapy.
Body: Scientists have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many therapies and can lead to relapses. The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.
Body: A study published in the journal Stem Cells describes a new and unexpected way to accelerate the maturation of induced pluripotent stem cells into cardiac muscle cells.
Body: Scientists have discovered how stem cells can develop resistance against viruses, a finding that could aid the development of stem cell therapies.
Body: Nerve cells derived from human stem cells often serve as the basis for research into brain diseases. However, these cells differ considerably in their quality and produce varying results. Scientists are therefore looking for simple cell models that lead to consistent results. Researchers describe a new model that consists of only one human nerve cell.
Body: Researchers have combined embryonic cells and liver cells in a new cell culture test. This combination lets them detect adverse effects that new medications may have on embryos early on in the drug development process.
Body: Researchers find that 'waves' of Hes1 and Ascl1 gene expression control the quiescent and active state of adult neural stem cells. Hes1 expression promotes quiescence and suppresses Ascl1, and knocking out Hes1 increases Ascl1 expression and subsequent adult neural stem cell activation.
Body: Recent work highlights a better way to grow smooth muscle cells, one of the two cellular building blocks of arteries, from pluripotent stem cells. This research is part of an effort to create artery banks -- similar to blood banks common today -- with readily-available material to replace diseased arteries during surgery.
Body: Researchers have developed a stem cell based model in order to study the resilience and vulnerability of neurons in the neurodegenerative disease ALS. The results can aid in the identification of new genetic targets for treatments protecting sensitive neurons.
Body: Our hair, skin and eyes are colored by a pigment called melanin, which is produced by pigment cells called melanocytes. Scientists have used stem cell technology to successfully create melanocyte precursor cells. These cells can be used in research on melanoma and other pigment cell-related illnesses.