Body: To understand what role an individual gene plays, biologists have, for 100 years, been using a trick of nature: While in principle, the genome in all cells of an organism is the same, mutations arise in individual cells. These mutations differentiate a cell from its neighbors, forming a 'genetic mosaic.' Now, researchers have advanced genetic mosaic analysis, making almost all genes in the mouse genome accessible to single-cell genetic mosaic analysis.
Body: Researchers have created what could be a key building block for assembling a synthetic kidney. They describe how they generate rudimentary kidney structures, known as organoids, that resemble the collecting duct system that helps maintain the body's fluid and pH balance by concentrating and transporting urine. The organoids provide a way to study kidney disease that could lead to new treatments and regenerative approaches for patients.
Body: New results allow the development of novel therapies for hereditary forms of intestinal cancer.
Body: Stem cell biologist have discovered that the pituitary gland in mice ages as the result of an age-related form of chronic inflammation. It may be possible to slow down this process or even partially repair it.
Body: A team of scientists has shown that the healing of skin blisters is driven by hair follicle stem cells, which delay their own development in the process.
Body: The promotion and marketing of unproven stem cell therapies is a global problem that needs a global solution, say experts. The authors of the paper call for the World Health Organization (WHO) to establish an advisory committee on regenerative medicine to tackle this issue and provide guidance for countries around the world.
Body: The chances of restoring fertility through sperm stem cell transplant are as random as a coin toss. But a team of scientists developed a new strategy that serves as a 'weighted coin' that can favorably rig the odds to achieve outcomes where fertility is successfully restored.
Body: Scientists are developing a promising approach for treating type 1 diabetes by using stem cells to create insulin-producing cells (called beta cells) that could replace nonfunctional pancreatic cells.
Body: Chemotherapy destroys stem cells, which then cannot develop into immune cells and become part of the body's defenses. There are drugs that can remedy this, but previously we did not know exactly how these drugs worked. Now, a new study details their function providing new knowledge that may improve stem cell transplantation and lead to better drug design in the future.
Body: In work that could one day help athletes as well as aging adults regenerate tissue more effectively, scientists increased the regeneration of muscle cells in mice by activating the precursors of muscle cells.