Body: Scientists have identified how low levels of the TET2 gene fuel the rapid growth of acute myeloid leukemia in animal models.
Body: Thanks to continuous advances in human stem cell research, studies that make use of embryo models are progressing quickly. This research offers both a scientific and ethical alternative to the use of embryos resulting from fertilized human eggs, and the appropriate ethical guidelines have been developed in parallel with the advances being made. A group of biologists and ethicists suggest additions to the current ethical framework that refine thinking about human embryology using embryo models to maximize benefits to society.
Body: A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases -- and for those who would like to eat meat, but don't want to kill animals.
Body: A research team has recently made a significant advancement in spinal cord injury treatment by using genetically modified human neural stem cells (hNSCs). They found that specifically modulating a gene expression to a certain level in hNSCs can effectively promote the reconstruction of damaged neural circuits and restore locomotor functions, offering great potential for new therapeutic opportunities for patients with spinal cord injury.
Body: Organoids have now been created from stem cells to secrete the proteins that form dental enamel, the substance that protects teeth from damage and decay. A multi-disciplinary team of scientists led this effort. This is a critical first step to the long-term goal to develop stem cell-based treatments to repair damaged teeth and regenerate those that are lost. Enamel is made during tooth formation by specialized cells called amelobasts. These cells die off after tooth formation is complete. Consequently, the body has no way to repair or regenerate damaged enamel.
Body: A study shows new steps toward more patients getting gene therapy.
Body: Promising preclinical results show hematopoietic stem cell therapy was effective in rescuing memory loss, neuroinflammation and beta amyloid build-up in a mouse model of Alzheimer's disease.
Body: Scientists have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children. Crucially, stem cells from a parent provide children with a new immune system that responds much better to immunotherapies.
Body: In skin, some aberrant adult epidermal stem cells turn on SOX9, kickstarting a process that ultimately activates cancer genes.
Body: Research found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn's disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage. The study offers a promising new and alternative treatment approach that avoids the pitfalls of current Crohn's disease medications, including diminishing effectiveness, severe side effects and increased risk of gastrointestinal dysfunction.