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February 12, 2024
Body: The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.
February 12, 2024
Body: Growing cartilage tissue in the lab could help patiens with injuries, but it is very hard to make the tissue grow in exactly the right shape. A new approach could solve this problem: Tiny spherical containers are created with a high-resolution 3D printer. These containers are then filled with cells and assembled into the desired shape. The cells from different containers connect, the container itself is degradable and eventually disappears.
February 9, 2024
Body: Researchers have captured time-lapse videos of stem cells dividing in growing plant roots. By watching how the cells divide in response to certain chemical signals over time, the team is uncovering new clues to how stem cells choose one developmental path over another.
February 7, 2024
Body: A tiny microfluidic device can improve cell therapy techniques for spinal cord injury patients. The device can remove a large percentage of stem cells that have not yet fully become spinal cord cells, which could potentially form tumors after being transplanted into a patient.
February 2, 2024
Body: A study has found an important connection between cancer, stem cells and the building blocks of cholesterol. Specifically, the research reveals how the enzyme FAXDC2 influences cancer cell growth and differentiation through its role in cholesterol synthesis, suggesting possible new approaches to cancer treatment.
January 31, 2024
Body: New research has uncovered a way to 'hack' neurons' internal clocks to speed up their development. The approach promises to accelerate research into neurological disease.
January 26, 2024
Body: Researchers describe how specific gene activity could potentially enhance immune cell production. The researchers wanted to understand the mechanism of why some hematopoietic stem cells produce more immune cells, while other stem cells produce fewer. The research team pioneered new techniques for understanding the quantitative association between immune cell production and gene expression in lab mice. The scientists labeled individual stem cells with genetic 'barcodes' to track their immune cell production. They then correlated the barcode tracking with measurements of gene expression activity. They also developed innovative bioinformatics approaches to characterize their quantitative association. The scientists identified nearly 40 genes that are related to immune cell production. They discovered associations between the activity of these genes and both the quantity and variety of immune cells produced.
January 11, 2024
Body: One of the biggest barriers to regenerative medicine is immunological rejection by the recipient, a problem researchers are one step closer to solving after genetically modifying pluripotent stem cells to evade immune recognition.
January 10, 2024
Body: A new CRISPR interference (CRISPRi) model explores how the pioneer transcription factor FOXA controls human endoderm differentiation during liver development, and how the pioneer transcription factor OCT4 influences the behavior of pluripotent stem cells. The unexpected findings could influence future organoid and cell reprogramming studies.
January 4, 2024
Body: Scientists have developed a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons. This marks the first time that scientists have succeeded in growing Purkinje cells that possess the molecular and electrophysiological features of functional neurons in an all-human system.