Body: New findings suggest that many of the mutations in cancer may simply be setting in stone a path already forged by the tumor stem cell's aberrant dialogue with its surroundings.
Body: Researchers have identified a new method for scheduling radiation therapy that could be as much as 22 percent more effective at killing cancer cells than current standard radiation treatment regimens.
Body: Intestinal bacteria composition is crucial to driving the recovery of neutrophils counts in the blood of mice following treatments such as stem cell transplants or chemotherapy.
Body: Leprosy is one of the world's oldest and most persistent diseases but the bacteria that cause it may also have the surprising ability to grow and regenerate a vital organ. Scientists have discovered that parasites associated with leprosy can reprogram cells to increase the size of a liver in adult animals without causing damage, scarring or tumors. The findings suggest the possibility of adapting this natural process to renew aging livers and increase healthspan -- the length of time living disease-free -- in humans.
Body: Blood stem cell transplantation is a radical but highly effective therapy for multiple sclerosis. A study has now examined in detail the way in which the treatment curbs the autoimmune disease and how the immune system regenerates afterwards. A better understanding of these mechanisms should help the treatment approach, currently approved in only a few countries, to gain wider acceptance.
Body: A new approach to stem cell therapy that uses antibodies instead of traditional immunosuppressant drugs robustly preserves cells in mouse brains and has potential to fast-track trials in humans, a new study suggests. Suppression with monoclonal antibodies enabled long-term survival of human stem cell transplants in mouse brains for at least six to eight months, while the cell grafts did not survive more than two weeks in most animals when using standard immunosuppressant drugs.
Body: Maternal consumption of a Western-style diet alters the transcriptional landscape of fetal blood stem cells in rhesus macaques, researchers report.
Body: Recent advances in immunotherapy for cancer have stimulated a plethora of studies aimed at developing T cells and Natural Killer (NK) cells in-vitro from pluripotent stem cells. Researchers have discovered a novel pathway based on Notch stimulation very early during the in-vitro differentiation that robustly support the emergence of T and NK cells from human induced Pluripotent Stem Cells (iPSC).
Body: In animal models, researchers found that intensive physical therapy in tandem with implanted neural stem cells increased tissue growth, repair and functionality in spinal cord injuries more than those treatments alone.
Body: Patient-derived parathyroid organoids (PTOs) could pave the way for future physiology studies and drug-screening applications, as shown in a new study.