Body: Researchers identify proteins that drive cancer stem cells. Targeting and suppressing a particular protein called galectin1 could provide a more effective treatment for glioblastoma, in combination with radiation therapy.
Body: The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy. Called Type 1 diabetes, this disorder can occur at any age and can be fatal if not carefully managed with insulin shots or an insulin pump to balance the body's sugar levels.
Body: Expression of the MyoD gene combined with exposure to three chemicals causes skin cells to become primitive muscle progenitors that can be maintained indefinitely in the lab and later coaxed into becoming mature muscle cells to treat muscle-related diseases. Skin-derived muscle progenitors are molecularly similar to muscle tissue stem cells, and muscle cells derived from these progenitors are more stable and mature than muscle cells directly converted from skin cells.
Body: A new study presents a detailed cellular atlas of the developing coronal suture, the one most commonly fused as a consequence of single gene mutations, leading to birth defects such as craniosynostosis. With an aim toward advancing new interventions for patients, researchers created the first detailed cell-by-cell description of how this suture develops. They identified 14 distinct types of cells in and around the developing suture and new genes that may be involved in generating and maintaining the stem cells that grow the skull bones on either side of the suture.
Body: Scientists have grown beating heart cells in the lab and shown how they are vulnerable to SARS-CoV-2 infection. In a new study, they used this system to show that an experimental peptide drug called DX600 can prevent the virus entering the heart cells.
Body: Researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers.
Body: Researchers have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.
Body: Heart attack, or myocardial infarction, is one of the leading causes of death worldwide. Although modern surgical techniques, diagnostics and medications have greatly improved early survival from these events, many patients struggle with the long-term effects of permanently damaged tissue, and the 5-year mortality rate remains high. Now, researchers have developed a minimally invasive exosome spray that helped repair rat hearts after myocardial infarction.
Body: There are striking similarities in the development of two types of specialized sensory cells: the so-called 'hair cells' that receive sound vibrations in the inner ear, and the Merkel cells that sense light touch at the surface of the skin. These developmental similarities are a legacy of shared evolutionary history.
Body: Scientists reveal that during hematopoietic regeneration, RNA expressed from a part of the genome considered 'junk DNA' is used by hematopoietic stem cells to get activated and proliferate. The study shows that these so-called transposable elements make RNA after chemotherapy and activate an immune receptor which induces inflammatory signals enhancing hematopoietic stem cell cycling and thus participating in the regeneration of the hematopoietic system.