Body: A team has mapped the location and spatial features of blood-forming cells within human bone marrow. Their findings confirm hypotheses about the anatomy of this tissue and provide a powerful new means to study diseases, ranging from noncancerous conditions, such as sickle cell anemia, to malignant conditions, such as acute leukemia, that affect bone marrow.
Body: New experimental evidence suggests that substances known as narrow-spectrum Wnt signaling inhibitors -- which could have fewer side effects than other related substances -- are capable of suppressing the growth of breast cancer tumors in mice.
Body: A team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the prospect of injection-free treatment closer for people with diabetes.
Body: Researchers have harnessed a combination of lab-grown cells to regenerate damaged heart muscle. The study addresses major challenges of using heart muscle cells, called cardiomyocytes, grown from stem cells -- takes a crucial step toward future clinical applications.
Body: A team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, possibly leading to new therapies for heart disease and cardiac damage.
Body: Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. Guiding iPSCs toward a target cell line has garnered much attention, but the process remains challenging. Now, researchers from Japan have discovered that an anti-nucleolin DNA aptamer, iSN04, can determine a cell’s lineage during differentiation. By demonstrating the generation of cardiomyocytes from murine pluripotent stem cells, their concept shows promise as a regenerative therapy.
Body: A biobank for all, in which a person from any background could find a bone marrow donor for a stem cell transplant, is a major goal for stem cell science. While repositories of cell lines that could be a match for most patients are successfully materializing in some countries with genetically homogenous populations like Japan and the United Kingdom, how many more we need for a universal solution remains unknown. Researchers estimate at least 559 distinct cell lines would be required to cover 95% of the more diverse, and globally representative, people of Brazil.
Body: A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development.
Body: A cellular signal essential to development of the skeleton increases abnormally during aging to weaken bones.
Body: Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.