Body: According to the Mayo Clinic, about 15% of couples are infertile, and male infertility plays a role in over one-third of these cases. Often, problems with sperm development are to blame. Now, researchers have found a way to deliver a protein important for sperm cell production directly to mouse testicles, where it restored normal sperm development and allowed previously infertile mice to father pups.
Body: Biologists reveal that tissue perturbations by chemotherapy agents promote stem cell expansion and that fibroblast cells exhibit unexpected, immune-like behavior.
Body: To make organoids grow faster, give them a squeeze, suggests a new study, which finds compressing cells, and crowding their contents, can coax them to grow and divide. The results may lead to faster way to grow artificial organs.
Body: Medical researchers have identified a mechanism that is likely to prevent hair loss.
Body: Researchers have generated mice lacking the estrogen receptor beta gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. This was not observed in male mice that lacked the ER-beta gene, suggesting that estrogen and its downstream signals may be a female-specific mechanism for muscle growth and regeneration.
Body: Researchers building a model of muscle damage in a cultured system found that components leaking from broken muscle fibers activate ''satellite cells,'' which are muscle stem cells. While attempting to identify the activating proteins, they found that metabolic enzymes, such as GAPDH, rapidly activated quiescent satellite cells and accelerated muscle injury regeneration. This is a highly rational and efficient regeneration mechanism, in which the damaged muscle itself activates satellite cells for regeneration.
Body: A team has developed a thermoresponsive nanotopography cell culture platform.
Body: Minor changes in immune cells can significantly affect the immune response, scientists have now discovered. Their findings could be relevant for stem cell therapy.
Body: Scientists have discovered that a specific type of molecule may stimulate stem cells to regenerate, reversing the inflammation caused by periodontal disease.
Body: In September 2015, the US National Institutes of Health placed a funding moratorium on research that involves introducing human pluripotent stem cells into animal embryos. To assess attitudes on human-animal chimeric embryo research, investigators conducted a survey among 430 Americans. The results of the survey found that 82% of people are supportive of at least some parts of this research.