Body: Researchers have used human stem cells to make pain-killing neurons that provide lasting relief in mice, without side effects, in a single treatment. The next step is to perform extensive safety tests in rodents and pigs, and then move to human patients suffering chronic pain within the next five years.
Body: Scientists have found evidence to support long-standing anecdotes that stress causes hair graying. Researchers found that in mice, the type of nerve involved in the fight-or-flight response causes permanent damage to the pigment-regenerating stem cells in the hair follicle. The findings advance knowledge of how stress impacts the body, and are a first step toward blocking its negative effects.
Body: A new study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort to make personalizable, durable blood stem cells.
Body: A new study suggests that extremely rare, harmful genetic mutations present in healthy donors' stem cells -- though not causing health problems in the donors -- may be passed on to cancer patients receiving stem cell transplants, potentially creating health problems for the recipients. Among the concerns are heart damage, graft-versus-host disease and possible new leukemias.
Body: Specifically programmed materials can, under specific conditions, encourage stem cells to transform into bone cells. To do this, scientists implemented a so-called shape-memory polymer in stem cell research.
Body: In the first-ever genome-scale analysis of the puberty process in humans, researchers outline distinct and critical changes to stem cells in males during adolescence.
Body: Researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system. Using human induced pluripotent stem cells, this novel approach combined a variety of techniques that enabled the development of three-dimensional groups of intestinal cells called organoids in vitro, which can expand disease treatment testing in the lab using human cells.
Body: The older we get the more our brains will find it difficult to learn and remember new things. The research group used a method to stimulate the small pool of neural stem cells that reside in the brain in order to increase their number and the number of neurons generated by those stem cells. Additional neurons could survive and form new contacts with neighboring cells in the brain of old mice.
Body: A drug designed to tackle diabetes could also be repurposed as the first treatment to prevent miscarriage by targeting the lining of the womb itself, according to a clinical trial.
Body: Study shows drug SVC112 stops production of proteins that cancer stem cells need to survive and grow.