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Stem Cells welcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The Journal covers all aspects of stem cells. The following sections include, but are not limited to, the topics listed:
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Stem Cells Translational Medicine welcomes original articles and concise reviews describing the clinically relevant translational aspects of stem cells and progenitor cells for cell-based therapy, tissue engineering and regenerative medicine from the bench to patient care. The Journal covers all clinical translational aspects of stem cells. The following sections include, but are not limited to, the topics listed:
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Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells
- Signaling pathways/factors regulating and/or initiating ESC/iPS cells pluripotency and differentiation
- Derivation and organization of primitive, early structures with or without tissue specificity
Tissue-Specific Stem Cells
- Regulation of and pathways that govern stem cell self-renewal and/or differentiation
- Cellular interactions and signaling pathways necessary for tissue specificity
- Molecules and signaling pathways that modulate homing or mobilization of tissue-specific stem/progenitor cells
- Functional properties of tissue-specific stem and progenitor cells
- Improving engraftment for efficient and less costly cellular therapy for adult stem cells
- Understanding and avoiding teratoma formation
Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics
- Mutagenesis, and epigenetic influences
- Surveys of gene and/or protein expression with a link to structure or function
- Quantitative measurements of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification
- Prediction of the outcome (efficacy or toxicity) of a drug or xenobiotic intervention in an individual based on a mathematical model of pre-intervention metabolite signatures
Cancer Stem Cells
- Cellular origin of cancer stem cells
- Genetic constraints, including epigenetic modifications, that influence growth process
- The cancer stem cell niche, and cancer stem cells as therapeutic targets
- Mathematical models of cancer cell evolution and mechanisms of survival
Translational and Clinical Research
- Studies describing new model systems with potential for drug development
- Translation into pharmaceutical, clinical or practical findings
Regenerative Medicine
- Potential applications for stem cell-based strategies in pathological conditions
- Tissue engineering and characterization of engineered tissues
- Medical device and artificial organ development
- Stem cell transplantation and technologies that will maintain, improve or restore the function of diseased organs
- Gene therapies for inherited diseases
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Human Clinical Articles
- First in human case studies
- Phase I/II clinical trials
- Negative clinical results
Pluripotent Stem Cells
- Derivation, characterization and differentiation for clinical use
- Cell banking
- Therapeutic potential
- Animal models
- Translational pre-clinical studies
- Clinical applications
- First in human case studies
- Phase I/II clinical trials
- Negative clinical results
Cord Blood
- Umbilical cord blood and tissue based therapies
- Accessory cell populations
- Ex-vivo expansion strategies
- Engineering and manufacturing of cord blood immune cells
- Modulation of endogenous cell and tissue repair
- Cord blood and cord tissue banking
- Malignant and non-malignant diseases treated by cord blood transplantation
- Cord blood and cord tissue in regenerative medicine
Fetal and Neonatal Stem Cells
- Derivation, characterization and differentiation for clinical use
- Cell banking
- Therapeutic potential
- Animal models
- Translational pre-clinical studies
- Clinical applications
- First in human case studies
- Phase I/II clinical trials
- Negative clinical results
Tissue-Specific Progenitor and Stem Cells
- Derivation, characterization and differentiation for clinical use
- Cell banking
- Therapeutic potential
- Animal models
- Translational pre-clinical studies
- Clinical applications
- First in human case studies
- Phase I/II clinical trials
- Negative clinical results
Cell-Based Drug Development, Screening, and Toxicology
- Derivation, characterization and differentiation
- In-vivo models
- In-vitro models
- Throughput systems
Enabling Technologies for Cell-Based Clinical Translation
- Cell tracking
- Cell delivery vehicles
- Biomaterials
- Devices
- Imaging
- Diagnostics
Cancer Stem Cells
- Characterization
- Therapeutic targets
- Animal models
- Translational pre-clinical studies
- Clinical applications
- First in human case studies
- Phase I/II clinical trials
- Negative clinical results
Standards, Protocols, Policies, and Regulations for Cell-Based Therapies
- Cell standards
- Intellectual property relevant to clinical translation
- Cell toxicology/ tumorigenesis and other assays
- Regulations for clinical trials
Manufacturing for Regenerative Medicine
- GMP aspects
- Cell-based processing/expansion
- Cell-based potency/storage
- Quality assurance/control
- Scale-up and production
- Cell-based therapies release criteria
- Regulations for manufacturing
Tissue Engineering and Regenerative Medicine
- Applications for cell-based strategies in pathological conditions
- Tissue engineering
- Medical device and artificial organ development
- Cell transplantation and technologies that will maintain, improve or restore the function of diseased organs
- Therapeutic potential
- Animal models
- Translational pre-clinical studies
- Clinical applications
- First in human case studies
- Phase I/II clinical trials
- Negative clinical results
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