Featured Articles


Safety and Efficacy of Adult Stem Cell Therapy for Acute Myocardial Infarction and Ischemic Heart Failure (SafeCell Heart): A Systematic Review and Meta‐Analysis

This study provides a comprehensive evaluation of the safety and efficacy of mesenchymal stem cell therapy for acute myocardial infarction and ischemic heart disease. Results from this systematic review suggest that this cellular therapy may be safe. A well‐designed, adequately powered randomized controlled trial with rigorous adverse event reporting and comprehensive assessment of cardiac function is warranted. This will help establish a definitive risk‐benefit profile of mesenchymal stromal cell therapy for ischemic heart disease.


Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells

Glioma-initiating cells (GICs) are implicated in tumor heterogeneity and therapeutic resistance of GBM. Here we demonstrate that the BRG1 subunit of the SWI/SNF chromatin remodeling complex plays critical roles in maintaining GICs in a stem-like state. Furthermore, we have identified a novel mechanism by which BRG1 regulates expression of TXNIP, which is a redox regulator and also negatively regulates glycolysis. We found that BRG1 regulates TXNIP through a STAT3-dependent pathway. We demonstrate that BRG1 plays a critical role in the drug resistance of GICs, and in GIC-induced tumorigenesis. Thus, the BRG1-STAT3-TXNIP axis is a potential therapeutic target in GBM.

 

Journal Club Discussions

November 25, 2018

New study highlights the exciting potential for autologous micro‐fragmented adipose tissue in the treatment of osteoarthritis in patients following an animal trial

Comment

Discuss

Article Scans

December 10, 2018
Researchers employing single-cell RNA seq report on the steps involved in the generation of functional hepatocyte-like cells from a novel stem cell source
December 10, 2018
The results of a new human trial suggest that mesenchymal stem cell therapy may represent an effective means to treat the inflammation associated with sepsis
December 10, 2018
Advanced bioprinting technique employing iPSC-derived cardiomyocytes and endothelial cells generates cardiac tissue constructs with improved functionality