Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.

 

Featured Articles - January 20, 2021

 

Human induced pluripotent stem cell‐derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung
Shaun M. Kunisaki, et al., STEM CELLS Translational Medicine

 

This study established a reproducible ex vivo model of lung development using transgene‐free human induced pluripotent stem cells generated from fetuses and infants with Bochdalek congenital diaphragmatic hernia (CDH). Both primary cell‐intrinsic and secondary causes of CDH lung hypoplasia were identified, and mechanical compression was associated with alterations in lung organoid epithelial and mesenchymal gene regulation.

 

 

Improving hematopoietic engraftment: Potential role of mesenchymal stromal cell‐derived extracellular vesicles
Silvia Preciado, et al., STEM CELLS

 

Hematopoietic stem cell transplantation remains the optimal platform for the development of new cellular therapies. Treatment of graft failure or poor graft function after transplantation remains an unmet medical need. Mesenchymal stromal cells are being evaluated clinically in this context. Furthermore, the extracellular vesicles derived from them represent a promising therapeutic tool with some advantages over the parental cells, but also with remarkable challenges, all of which are covered in this article.

 

Article Scans

iPSCs and Advanced Screening Support Drug Discovery for Atrial Fibrillation

Advanced in vitro drug screening platform may significantly accelerate the identification of novel drugs for the treatment of atrial fibrillation


DHODH Inhibition –Ensuring the Safety of Pluripotent Stem Cell-based Regenerative Approaches

A new study provides evidence for the utility of DHODH inhibitors such as brequinar in the development of safe and effective PSC‐based therapies


Increased Wnt/β-catenin Signaling Allows Overcrowded Stem Cells to Self-renew

Cellular physical properties can promote intestinal stem cell self-renewal by inducing intracellular crowding and maintaining an elevated response to Wnt ligands