The epigenetic modifier chromodomain helicase DNA‐binding protein 7 (CHD7) is known to have important roles in development, neural stem cell maintenance, and some cancers. The study finds for the first time that ischemic microenvironments repress CHD7 levels in neural progenitors and brain tumor‐initiating cells/cancer stem cells. Results of the study also demonstrate that reduced levels of CHD7 in neural progenitors or brain tumor‐initiating cells increase angiogenesis. The results may have important implications for development, stem cells, and cancer.
This study demonstrates the feasibility of incorporating perfluorocarbon (PFC) into human glial‐restricted progenitors for in vivo 19F magnetic resonance imaging. Central to the use of PFC for clinical trials of transplantation into patients with diseases of the brain and spinal cord, including ALS, is the demonstration that PFCs do not significantly alter the glial identity of the Q‐Cell product. Finally, PFCs did not interfere with the capacity for differentiation into astrocytes either in vitro or following transplantation into the ventral horn of the mouse spinal cord and can be visualized in the brain using 19F MRI following transplantation. These studies form the foundation for future 19F MRI imaging studies using large animal and, eventually, human clinical trials.
Research identifies hBM-MSC derived factors that promote islet regenerative and may permit the development of cell‐free therapies for diabetic patients