Featured Articles - July 19, 2021
Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues
Enrico Ragni, et al., STEM CELLS Translational Medicine
The therapeutic potential of human amniotic membrane-derived mesenchymal stromal cells (hAMSCs) has been addressed to both soluble factors and extracellular vesicles (EVs). This study characterized the abundance of 200 factors and 754 EV-miRNAs released by hAMSCs. Identified molecules share protective signals in those contexts where inflammation and degeneration have to be counteracted, such as osteoarthritic joints or pathological tendons, and support preliminary in vitro and preclinical studies. These data allow for prediction of a broader disease-targeted clinical efficacy, as well as the setup of potency and release assays to fingerprint clinical-grade batches of hAMSCs cell-free products.
Type 2 diabetes mellitus (T2DM) is a serious disease with high morbidity and mortality around the world. In the course of the disease, immune dysfunction has been identified as a key pathogenic factor and also deemed as a potential therapeutic target. Remarkably, mesenchymal stromal cells (MSCs) possess pivotal immunoregulatory function mainly via paracrine mechanism. This review reports on the plasticity and underlying mechanisms of MSC-mediated immune modulation and further uncovers the therapeutic potential of MSCs for T2DM.
A new study assesses the safety and effectiveness of allogenic SHED transplantation in type 2 diabetic patients and notes those factors regulating therapeutic efficacy
O‐GlcNAcylation plays a critical role in maintaining satellite cell health and function in both normal and injured skeletal muscle
New research reports on "iBlastoids" - blastocyst-like structures formed from iPSCs that model several aspects of human blastocyst biology
Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.