Featured Articles

 

Intra‐Articular Injection of Autologous Adipose Tissue‐Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo‐Controlled Clinical Trial
Woo‐Suk Lee, et al., STEM CELLS Translational Medicine

 

This study found that rapamycin‐activated autophagy could protect cartilage endplate (CEP) from inflammation‐induced degeneration in a mouse model. Moreover, this study demonstrated that rapamycin‐activated autophagy promotes the expression of antioxidant proteins, thus affecting scavenging ROS, reducing cell senescence, and maintaining the differentiation potential of cartilage endplate stem cells (CESCs). Nrf2/Keap1 signaling is a pivotal pathway in controlling the expression of antioxidant proteins, and it was found that activation or inhibition of autophagy affects the expression and nuclear translocation of Nrf2, thus mediating CEP degeneration induced by TNF‐α. These findings are beneficial for the prevention of disease and for the development of clinical therapies.

 

 

Rapamycin Induced Autophagy Inhibits Inflammation‐Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells
Rui Zuo, et al., STEM CELLS

 

This study found that rapamycin‐activated autophagy could protect cartilage endplate (CEP) from inflammation‐induced degeneration in a mouse model. Moreover, this study demonstrated that rapamycin‐activated autophagy promotes the expression of antioxidant proteins, thus affecting scavenging ROS, reducing cell senescence, and maintaining the differentiation potential of cartilage endplate stem cells (CESCs). Nrf2/Keap1 signaling is a pivotal pathway in controlling the expression of antioxidant proteins, and it was found that activation or inhibition of autophagy affects the expression and nuclear translocation of Nrf2, thus mediating CEP degeneration induced by TNF‐α. These findings are beneficial for the prevention of disease and for the development of clinical therapies.

 

Article Scans

Single MSC Injection Provides Functional improvements and Pain Relief for Knee Osteoarthritis Patients

Trial of intra‐articular injections of autologous adipose-derived MSCs in patients with knee osteoarthritis provides proof of functional improvement and pain relief


Sympk-Oct4 Promotes Self-renewal and Pluripotency of Mouse Embryonic Stem Cells

New findings suggest that the Sympk scaffold protein interacts with Oct4 to promote self‐renewal and pluripotency in mouse ESCs and preserve genome integrity


Senescent NPCs in Progressive Multiple Sclerosis: A New Therapeutic Target?

New research establishes senescent NPCs as a contributor to and potentially reversible factor in progressive MS while also suggesting MS as an aging-related disease