Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.

 

Featured Articles - April 12, 2021

 

Safety and efficacy of Wharton's jelly‐derived mesenchymal stem cells with teriparatide for osteoporotic vertebral fractures: A phase I/IIa studys
JeongHyun Shim, et al., STEM CELLS Translational Medicine

 

This article reports the engineering of cardiac repair competent stem cells using Brachyury, a mesodermal transcription factor. Brachyury transfection, achieved by the microencapsulated‐modified‐mRNA technique, induces naïve mesenchymal stem cells to adopt cardiopoietic fate endowed with cardioreparative proficiency. Evolving the traditional cardiopoiesis process, requiring multiple recombinant proteins, the newly streamlined single‐gene approach would simplify cell procurement, advancing clinical translation.

 

 

Robust parameter design of human induced pluripotent stem cell differentiation protocols defines lineage‐specific induction of anterior‐posterior gut tube endodermal cells
Ryota Yasui, et al., STEM CELLS

 

Robust parameter design (RPD) is a multifactorial condition screening tool utilized mainly in industry for developing qualified product design and manufacturing processes. The authors utilized RPD for establishing human induced pluripotent stem cell differentiation protocols, which led to the specific induction of anterior foregut, hepatic, pancreatic, or mid‐hindgut cells, while increasing the efficiency of the screening in 243‐fold (18 vs 4374) compared with that of a brute‐force approach. This screening further clarified the contribution of each investigated cell signaling pathway to the lineage specification, which facilitated the strategic protocol optimization. RPD should be a promising tool for efficient optimization of pluripotent stem cell differentiation protocols toward desired end products.

 

Article Scans

MSCs Relevant for ARDS Therapy Display Resistance to SARS‐CoV‐2 Infection

A new study defines the ACE2 and TMPRSS2 expression profile in human MSCs of adult and fetal origin and explores their permissivity to SARS‐CoV‐2 infection


Stem Cell-derived Exosomes – A New Therapeutic Option for a Common Cause of Back Pain?

How cartilage endplate stem cell-derived exosomes may prevent intervertebral disc degeneration and significantly slow the onset of lower back pain


Identifying the Gene Regulatory Networks Controlling Efficient Human iPSC Chondrogenesis

Inhibiting the expression of specific WNTs and MITF during the chondrogenic differentiation of human iPSCs significantly increases chondrocyte homogeneity