Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response
Johannes Maximilian, et al., STEM CELLS Translational Medicine
This study focused on reduced bone regeneration after severe bone infections. To restore bone healing in this context, stem cells gained from fat tissue (adipose-derived stem cells) were transferred to bony defects right after surgical treatment of infected bones in mice. The gained study results could help to improve therapy of bone infections and moreover contribute to the understanding of stem cell interaction in bone in an inflammatory state.
This study describes how homophilic interactions via CD166 that is expressed on hematopoietic cells augments the functional potential of these cells. This study also uses single-cell RNAseq to identify pathways activated by the engagement of CD166 on the surface of these cells to enhance the hematopoietic function of stem and progenitor cells.
A new study combines skeletal myocyte differentiation of mutation-carrying hiPSCs with drug screen to detect small molecules that boost dysferlin levels
Neonatal astrocytes, but not adult astrocytes, promote neural stem cell proliferation and the repair of brain injury via high expression of Tenascin‐C
New research establishes a link between the functional decline of the neurogenic niche in the aging mouse subventricular zone and immune cell infiltration