Process parameter development for the scaled generation of stem cell-derived pancreatic endocrine cells
Diepiriye G. Iworima, et al., STEM CELLS Translational Medicine
Diabetes is a global pandemic that can potentially be treated using stem cell-derived pancreatic progenitors and hormone-secreting cells. The ability to generate stem cell-derived derivates at sufficient scales is a critical step toward using these cells to treat diabetes. This article reports on some critical process parameters and quality attributes that affect the final stem cell-derived product.
Transient receptor potential vanilloid 4 as a regulator ofinduced pluripotent stem cell chondrogenesis
Vincent P. Willard, et al., STEM CELLS
Transient receptor potential vanilloid 4 (TRPV4) is an osmo- and mechanosensitive cation channel that is highly expressed in chondrocytes. This study examined the hypothesis that TRPV4serves as a marker as well as a regulator of chondrogenesis in induced pluripotent stem cells. During the process of chondrogenesis, Trpv4 expression mirrored the expression of classic chondrogenic markers (e.g., Sox9, Acan, and Col2a1). Furthermore, intermittent daily activation of TRPV4 significantly increased cartilaginous matrix production. An improved understanding of the role of TRPV4 in chondrogenesis may provide new insights into the development of new therapeutic approaches for diseases that affect cartilage.
A new study describes autologous adipose micro-grafts as a safe and effective treatment for tendinopathy in sheep, which supports this cell therapy in human patients
A transcriptional comparison of hematopoietic stem cell niches identifies PGI2 as an endosteal bone marrow-associated factor that functions at cell-intrinsic and cell-extrinsic levels
New research describes CTCF as a significant barrier to the conversion of mouse embryonic stem cells into a two cell-like totipotent state
Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.