Featured Articles


Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma
Ligia L. Castro, et al., STEM CELLS Translational Medicine


Although a single dose of mesenchymal stromal cells (MSCs) administered therapeutically was unable to ameliorate lung remodeling in house dust mite (HDM)-induced allergic asthma, multiple doses of MSCs effectively reduced both lung inflammation and remodeling, while improving lung mechanics. Nevertheless, multiple doses of MSCs also resulted in immunosuppressive effects. This should be taken into account for future clinical trials in patients with severe asthma.



CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials
Lijun Ding, et al., STEM CELLS


Perivascular adventitial cells include multipotent progenitor cells giving rise in culture to mesenchymal stem/progenitor cells. The present data show that a subset of human adventitial cells natively express the CD10 surface marker, regulated by sonic hedgehog/GLI1 signaling. Purified CD10+ adventitial cells exhibit high proliferative, clonogenic and osteogenic potentials, suggesting a role in pathologic vascular remodeling.


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