Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma
Ligia L. Castro, et al., STEM CELLS Translational Medicine
Although a single dose of mesenchymal stromal cells (MSCs) administered therapeutically was unable to ameliorate lung remodeling in house dust mite (HDM)-induced allergic asthma, multiple doses of MSCs effectively reduced both lung inflammation and remodeling, while improving lung mechanics. Nevertheless, multiple doses of MSCs also resulted in immunosuppressive effects. This should be taken into account for future clinical trials in patients with severe asthma.
Perivascular adventitial cells include multipotent progenitor cells giving rise in culture to mesenchymal stem/progenitor cells. The present data show that a subset of human adventitial cells natively express the CD10 surface marker, regulated by sonic hedgehog/GLI1 signaling. Purified CD10+ adventitial cells exhibit high proliferative, clonogenic and osteogenic potentials, suggesting a role in pathologic vascular remodeling.
Trial provides evidence for the safety and feasibility of cord blood cell infusion after birth in preterm neonates to reduce the rate of complications
The enhancement of glymphatic function by mesenchymal stem cell therapy improves the distribution and efficacy of mutant huntingtin targeting antisense oligonucleotides
In vivo analysis identifying both tendon stem cells and the cells behind fibrotic scarring may aid the construction of enhanced tendon regeneration approaches