This study details the creation of a large novel, sex, and ancestry balanced, cohort of primary dermal fibroblast and derived induced pluripotent stem cells (iPSC) from 80 healthy human donors. Creation of this cohort allowed researchers to determine key factors involved in the efficiency by which to produce iPSCs. Specifically, components of the SWI/SNF family of epigenetic enzymes, donor age, and donor ancestry all correlated with proficient generation of iPSCs. The results from these studies will have broad implications in Stem Cell Biology and Regenerative Medicine. Additionally, these cohorts will allow for the creation of sophisticated cell‐based models for mechanism of action studies, pharmaceutical development, and toxicity assessments.
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Parkinson’s Disease (PD) still has no cure and the use of adult stem cell-based strategy as emerged as a potential tool for PD. In recent years, neural stem cells have stand out as a valid therapeutic option, and it has been suggested that the beneficial effects caused by these cells could be related with their secretome and its trophic capability. Herein, we demonstrated that the injection of human neural progenitor cells (hNPCs) secretome better modulated the DA neurons survival (in substantia nigra and striatum) and ameliorate the motor deficits of a 6-OHDA rat model of PD, when compared to undifferentiated hNPCs transplantation. Overall, this work provided important insights on the potential use of hNPCs secretome as a therapeutic tool for PD.
Epigenetic Enzymes, Age, and Ancestry Regulate the Efficiency of Human iPSC Reprogramming
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A new study of the blind mole rat uncovers a link between adipose stem cell migration, intratumoral angiogenesis, and cancer resistance
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