We are pleased to announce that the impact factors for both STEM CELLS and STEM CELLS Translation Medicine increased in the 2020 JCR! Thank you to our Editors, Authors, and Readers for all of your support and contributions.

 

Featured Articles - July 19, 2021

 

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues
Enrico Ragni, et al., STEM CELLS Translational Medicine

 

The therapeutic potential of human amniotic membrane-derived mesenchymal stromal cells (hAMSCs) has been addressed to both soluble factors and extracellular vesicles (EVs). This study characterized the abundance of 200 factors and 754 EV-miRNAs released by hAMSCs. Identified molecules share protective signals in those contexts where inflammation and degeneration have to be counteracted, such as osteoarthritic joints or pathological tendons, and support preliminary in vitro and preclinical studies. These data allow for prediction of a broader disease-targeted clinical efficacy, as well as the setup of potency and release assays to fingerprint clinical-grade batches of hAMSCs cell-free products.

 

 

Mesenchymal stromal cell-mediated immune regulation: A promising remedy in the therapy of type 2 diabetes mellitus
Ji Chen, et al., STEM CELLS

 

Type 2 diabetes mellitus (T2DM) is a serious disease with high morbidity and mortality around the world. In the course of the disease, immune dysfunction has been identified as a key pathogenic factor and also deemed as a potential therapeutic target. Remarkably, mesenchymal stromal cells (MSCs) possess pivotal immunoregulatory function mainly via paracrine mechanism. This review reports on the plasticity and underlying mechanisms of MSC-mediated immune modulation and further uncovers the therapeutic potential of MSCs for T2DM.

 

Article Scans

SHED Therapy – A Safe and Effective Means to Treat Type 2 Diabetes?

A new study assesses the safety and effectiveness of allogenic SHED transplantation in type 2 diabetic patients and notes those factors regulating therapeutic efficacy


Post-translational Protein Modification Regulates Muscle Satellite Cell Function

O‐GlcNAcylation plays a critical role in maintaining satellite cell health and function in both normal and injured skeletal muscle


iBlastoids – The Future of Human Blastocyst Research?

New research reports on "iBlastoids" - blastocyst-like structures formed from iPSCs that model several aspects of human blastocyst biology





 

 

Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.