Featured Articles


Perfluorocarbon Labeling of Human Glial‐Restricted Progenitors for 19F Magnetic Resonance Imaging

This study demonstrates the feasibility of incorporating perfluorocarbon (PFC) into human glial‐restricted progenitors for in vivo 19F magnetic resonance imaging. Central to the use of PFC for clinical trials of transplantation into patients with diseases of the brain and spinal cord, including ALS, is the demonstration that PFCs do not significantly alter the glial identity of the Q‐Cell product. Finally, PFCs did not interfere with the capacity for differentiation into astrocytes either in vitro or following transplantation into the ventral horn of the mouse spinal cord and can be visualized in the brain using 19F MRI following transplantation. These studies form the foundation for future 19F MRI imaging studies using large animal and, eventually, human clinical trials.


Chromodomain Helicase DNA‐Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis

The epigenetic modifier chromodomain helicase DNA‐binding protein 7 (CHD7) is known to have important roles in development, neural stem cell maintenance, and some cancers. The study finds for the first time that ischemic microenvironments repress CHD7 levels in neural progenitors and brain tumor‐initiating cells/cancer stem cells. Results of the study also demonstrate that reduced levels of CHD7 in neural progenitors or brain tumor‐initiating cells increase angiogenesis. The results may have important implications for development, stem cells, and cancer.

 

Journal Club Discussions

April 1, 2019

Research identifies hBM-MSC derived factors that promote islet regenerative and may permit the development of cell‐free therapies for diabetic patients

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Article Scans

April 15, 2019
Systematic evaluation of methods to differentiate dopaminergic neurons from hPSCs identifies measures to improve comparisons and clinical translation
April 15, 2019
Researchers investigate the hypothesis that hyperglycemia may influence autophagy in neural stem cells and that melatonin may act as a protective agent
April 15, 2019
Activation of retrotransposons contributes to inflammaging, although the L1 reverse transcriptase represents a target for age-associated disorder treatment