Regenerative Medicine Manufacturing Society (RMMS) is partnering with STEM CELLS Translational Medicine to build a freely accessible collection of shared resources across three areas: models; cell therapies; and technologies. These resources will bring together the scientific community and highlight how the field of regenerative medicine is uniquely positioned to fight the COVID-19 pandemic.

 

Featured Articles - October 29, 2020

 

CRISPR/Cas9‐mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes
John W. Ostrominski, et al., STEM CELLS Translational Medicine

 

In vivo imaging techniques are imperative to guide clinical translation of cell‐based therapeutics; however, current strategies are limited by immunogenicity and potential genotoxicity. In this proof‐of‐principle study, site‐specific delivery of the sodium/iodide symporter (NIS) gene via CRISPR/Cas9 enabled sensitive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CM) in a clinically relevant model of myocardial infarction, and NIS‐positive iPSC‐CMs retained electrophysiological characteristics comparable to controls. Featuring a superior safety profile, this approach offers wider applications in both the preclinical and clinical development of cardiac cell therapies.

 


 

Platform to study intracellular polystyrene nanoplastic pollution and clinical outcomes
Sanja Bojic, et al., STEM CELLS

 

A plethora of plastic types, particle sizes, and the lack of a reliable model makes studying the impact of rising environmental plastic pollution on human health very challenging. Here, the authors describe a new platform to estimate gene changes and signaling pathways altered in response to the exposure of preimplantation human embryos and human induced pluripotent stem cells to nanosized polystyrene items. The platform includes computational big data for processing essential disease modeling and allows clinical interpretation of nanosized plastic, which could be relevant for any kind of intracellular pollution.

 

Article Scans

A new study reports the intrinsic neurotrophic properties of decellularized scaffolds, thereby supporting their application in muscle regeneration approaches

The processing of cord blood under lower-than-normal temperatures enhances the numbers of phenotypically and functionally defined self‐renewing HSCs

Researchers use induced pluripotent stem cells grown and differentiated within an extracellular matrix bioink to develop a chambered muscle pump