More is not always better in reprogramming, as researchers show that a set of factors which reprogram cells with low efficiency are developmentally superior to other more “efficient” reprogramming cocktails.
Motor neuron diseases encompass a range of neurological disorders that affect the muscles and movement of the body. These disorders are caused by the progressive degeneration of motor neurons, often leading to paralysis and ultimately death in patients. Can a stem cell-based strategy provide replacement cells?
Scientists link a common mutation in patients with neuropsychiatric disorders to deregulated neuronal synapses through generating patient-specific induced pluripotent stem cells and following their differentiation
Researchers find that neural stem cells, but not terminally differentiated neural cell types, differentiated from iPSCs can revert to a pluripotent like state and potentially problematic for use in transplants.
Using a non-human primate model, researchers demonstrate that sufficient numbers of human ESC-derived cardiomyocytes can be produced, stored, and transplanted, leading to good levels of engraftment and electrical coupling
The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications.