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Can Engineered Bacteria Bring Gene-edited Human Stem Cells to the Clinic?

Researchers describe how a bacterial infection-based protein delivery strategy can mediate effective and safe gene editing in human pluripotent stem cells.

New Pluripotent Stem Cell Type with Enhanced Therapeutic Value Described

Researchers describe "region-selective" pluripotent stem cells from mouse and humans, and highlight their therapeutic potential.

Safer and Better? Alternative Reprogramming Technique Used for Glaucoma Cell Replacement Therapy

A non-nucleic acid based reprogramming strategy promises to provide a safe and effective treatment for lost retinal cells in glaucoma sufferers.

Understanding Heart Defects in Down's Syndrome using ESC Models

Researchers use matched human embryonic stem cell lines to understand the perturbed developmental mechanisms which lead to heart defects in Down's Syndrome patients.

Reprogramming Revealed Using a Mass-terly Strategy

The implementation of mass cytometry analysis to the reprogramming process has illuminated the early chaotic stages of reprogramming and has uncovered essential new pathways controlling the process.

Bud-ding New Strategy for Organ Formation Shows Success!

Researchers combine multiple stem/progenitor types to generate miniature functional organ “buds” which may be useful in developmental and disease modelling, and in the future, tissue replacement.

iPSCs and CRISPR - Daring Duo Combine to Fight Sickle Cell Disease

Gene editing technology, combined with iPSC generation and a clinically relevant differentiation strategy combine to offer a new treatment for a blood borne genetic disease

Patient Specific Stem Cell-derived Platelets - Coming to a Clinic Near You?

Researchers take the first steps towards creating a clinically-relevant source of platelets from human induced pluripotent stem cells.

Long Term Success Brings Autologous iPSC-Derivatives Closer to the Clinic

For the first time, researchers demonstrate long term success of a cell replacement therapy using autologous induced pluripotent stem cell derivatives

iPSCs - Quick Stepping Towards the Clinic?

A new strategy to create patient specific induced pluripotent stem cells brings these cells closer to application in the clinic.

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