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ESCs/iPSCs

Effector of G Protein-coupled Receptors Identified as Novel Pluripotency Factor

New research highlights the influence of a GPCR effector on the maintenance of hESC pluripotency and the successful reprogramming of fibroblasts to hiPSCs 

Gene-editing in Induced Pluripotent Stem Cells Reveals How Risk Locus Influences Cardiovascular Disease

Researchers describe how a risk locus impacts VSMC related genes expression, thereby influencing the risk of coronary artery disease and possibly other CVDs 

Moving Pluripotent Stem Cell-derived Hepatocytes One Step Closer to the Clinic

New research highlights the suitability of hepatocytes differentiated from cGMP human pluripotent stem cells for therapeutic applications in human patients

Induced Pluripotent Stem Cells and CRISPR/Cas9 Combine to Develop in vitro Chondrogenesis Platform

A new study shows how genome editing of induced pluripotent stem cells may pave the way for the development of in vitro chondrogenesis platforms

Mouse Brain Transplantation Permits in vivo Imaging Analysis of Human Neuron Dynamics

Researchers study human iPSC-derived neurons following transplantation into the mouse brain to understand healthy and diseased neuronal dynamics in vivo

First Report of Bipaternal Mice: Dad’s Turn to Cross the Same-sex Reproduction Barrier

A new study explores DNA methylation, imprinting barriers, and uniparental reproduction and reports the first generation of full-term bipaternal mice

Large Novel Cohort Highlights the Factors Influencing Human Reprogramming

Researchers discover that donor age, ancestry, and chromatin remodeling complex component expression significantly affect reprogramming efficiency

The Search for Small Molecule Inhibitors Uncovers an Unexpected Cardiomyogenesis Route

Researchers report the identification of small molecules that promote cardiomyogenesis through the TGFβ pathway and not the Wnt/β‐catenin pathway

Large-scale Generation of Light-Responsive Retinal Organoids for Drug Screening

An optimized differentiation strategy permits the large-scale production of retinal organoids that display light responsiveness and use in drug testing

Glycoproteomic Analysis Reveals New Pluripotency-associated Cell Surface Marker

Researchers discover a new cell surface glycoprotein that plays a crucial role in the stemness and proliferation of human embryonic stem cells

 

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