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Innate Immune Pathway Stimulation Enhances Reprogramming Strategies

A new study learns that the activation of the innate immune system enhances the reprogramming of somatic cells into other fates

Will an Enhanced Endothelial Cell Differentiation Strategy Leave CVDs “Quaking” in their Boots?

The overexpression of an RNA binding protein enhances endothelial cell differentiation from induced pluripotent stem cells and may improve the treatment of cardiovascular disease patients

Pluripotent Stem Cells Retain Innate Species-specific Developmental Timing

A new study indicates that the timing of the in vitro differentiation of pluripotent stem cells reflects species-specific rates of development

New Differentiation Strategy Aims to Boost Cell Therapies for Vascular Disease

A new study describes an improved protocol for the efficient differentiation of endothelial cells from pluripotent stem cell sources and highlights the importance of the MAPK and PI3K signaling pathways

Optimized Platform Boosts Studies of Rare Neurodevelopmental Disorders

A new study describes a quick and efficient means to generate, gene-edit, and differentiate induced pluripotent stem cells in order to study rare neurodevelopmental disorders

Totipotency – Just an miRNA Away?

A new study shows that the loss of a single microRNA is sufficient to endow mouse pluripotent stem cells with totipotent characteristics

Search and Destroy: Eliminating Pluripotent Cells from Differentiating Cultures

A new study describes a new synthetic hybrid molecule that can selectively target and eliminate pluripotent cells and reduce the tumorigenic threat of cell transplantation strategies

TGFβ Inhibition – The Key to Endothelial Cell-based Therapeutics?

New research discovers a means to boost the growth and function of endothelial cells derived from human pluripotent stem cells

Pluripotency takes a Pause for Thought!

Researchers discover that modulation of a nutrient-sensing pathway can induce a “paused” state of pluripotency

Senescence - An Unexpected Helper for in vivo Reprogramming

New research into in vivo reprogramming highlights cellular senescence as an important regulator

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