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ESCs/iPSCs

iPSCs Reduce Pulmonary Endothelial Leakage

Induced pluripotent stem cells (iPSCs) significantly diminish the severity of endotoxin‐induced acute lung injury (ALI); however, the interactions that occur between iPSCs and the vascular endothelium remain unclear.

iPSC-based Small Molecule Screening Reveals Possible Dysferlinopathy Treatment Approach

A new study combines skeletal myocyte differentiation of mutation-carrying hiPSCs with drug screen to detect small molecules that boost dysferlin levels

Engineered hiPSC-CMs for Action Potential Assessments

While genetically encoded fluorescent voltage indicators can report on action potentials in human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs), the transfection process presents several drawbacks. To solve this problem, researchers from the laboratory of Deborah K.

Functional APC Required for ESC Self-renewal

To study the role of Adenomatous polyposis coli (APC), a negative regulator of Wnt/β‐catenin signaling, in human embryonic stem cells (ESCs), researchers from the lab of Dalit Ben‐Yosef

Tracking Pluripotent Stem Cells Through the Cell Cycle

FUCCI technology tracks cell division in primed hPSCs to highlight the importance of distinct signaling pathways in regulation of developmental potential

Mouse Embryonic Stem Cell Study Highlights the Factors Controlling the Totipotent State

Researchers combine the efficient formation of 2C-like cells from mESC cultures with CRISPR/Cas9 to identify regulators linked to the totipotent state

New Study Highlights Proper Metabolic Reprogramming in iPSC Generation

A study compares metabolic profile of iPSCs generated under atmospheric or physiological oxygen levels and evaluates their response to elevated oxygen levels

β-Cell Mass Formation in Stem Cell-Derived Implants

A recent study from the lab of Daniel G. Pipeleers (Brussels Free University, Belgium) reported on ex vivo device‐encapsulated human embryonic stem cell‐derived pancreatic endoderm implants in mice that established a metabolically adequate functional β‐cell mass. Now, Robert et al.

Lack of Aicda-mediated Suppression of Fgf/Erk Signaling Inhibits Naïve Pluripotency

A new study reports that while stable reprogramming can occur without the presence of Aicda, resultant mouse iPSCs fail to achieve naïve pluripotency 

Roles of SMYD2 in Mesendoderm Commitment of hESCs

A recent article from the laboratory of Huang‐Tian Yang (University of Chinese Academy of Sciences, Shanghai, China) explored

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