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ESCs/iPSCs

New Study Highlights Proper Metabolic Reprogramming in iPSC Generation

A study compares metabolic profile of iPSCs generated under atmospheric or physiological oxygen levels and evaluates their response to elevated oxygen levels

β-Cell Mass Formation in Stem Cell-Derived Implants

A recent study from the lab of Daniel G. Pipeleers (Brussels Free University, Belgium) reported on ex vivo device‐encapsulated human embryonic stem cell‐derived pancreatic endoderm implants in mice that established a metabolically adequate functional β‐cell mass. Now, Robert et al.

Lack of Aicda-mediated Suppression of Fgf/Erk Signaling Inhibits Naïve Pluripotency

A new study reports that while stable reprogramming can occur without the presence of Aicda, resultant mouse iPSCs fail to achieve naïve pluripotency 

Roles of SMYD2 in Mesendoderm Commitment of hESCs

A recent article from the laboratory of Huang‐Tian Yang (University of Chinese Academy of Sciences, Shanghai, China) explored

Epigenetics and Pluripotent States: A Review

There exist various pluripotent states along with early embryonic development in mammals: from totipotency to naïve pluripotency to primed pluripotency. While these pluripotent stem cell populations can both self-renew and differentiate into cells representative of the three germ layers, studies have not made it clear that each cell types displays a unique epigenetic profile.

A Role for hnRNP‐K in Regulating Open Chromatin in Embryonic Stem Cells

hnRNP‐K bindS at regions that overlap binding sites for crucial transcription factors and histone modifications associated with permissive chromatin

Drug Screening for Dysferlinopathy Using iPSCs

Given the lack of effective pharmaceutical approaches to the treatment of the progressive muscle disorder dysferlinopathy, researchers led by Yuko Kokubu and Hidetoshi Sakurai (Kyoto University, Japan) sought to use screen myocytes from induced pluripotent stem cells derived from a dysferlinopathy patient (Miyoshi myopathy).

Comparative Study Highlights Optimal Strategy for Retinal Cell Generation from hPSCs

Cell line‐specific differences and embryoid body maintenance methods contribute to the differing abilities of hPSCs to produce laminated retinal tissue

Identification of Human Pluripotent Founder Cells

N-cadherin positive hPSCs function in the initiation and establishment of pluripotency and have now been postulated as human pluripotent “founder” cells

IDO1 Controls Embryonic Stem Cell Metabolism

A recent STEM CELLS article from the laboratories of Xuemei Fu and Yan

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