You are here

Direct Reprogramming

ProNGF Controls Adult Hippocampal Neurogenesis

To explore the role of proNGF, the precursor of nerve growth factor (NGF), on the biology of adult neural stem cells (NSCs), researchers from the labs of Antonino Cattaneo

Refining and Defining the Optimal Recipe for Astrocytes to Neuron Conversion

Researchers refine a chemical cocktail to four small molecule drugs and define the signaling pathways vital for astrocytes-neuron conversion

Direct Reprogramming from Blood to Brain May Boost Complex Genetic Studies of Disease

A new study suggests that direct reprogramming from blood to brain can boost our understanding of how complex genetic alterations can influence neuro-related diseases and disorders

A Direct Solution to a Schwann cell Problem?

A new study suggests that directly reprogrammed Schwann cells boast a similar regenerative activity to primary Schwann cells derived from patients

3D Scaffolds – The Way Forward for Improved Neural Therapies?

New research finds that directly reprogrammed neurons grown on a 3D growth substrate may represent a new means so boost survival and functionality after transplantation into the brain

Mogrify – Cell Conversion Made Easy?

A new computer program aims to streamline the process of direct reprogramming/transdifferentiation by predicting the reprogramming factors needed for any conversion

Reprogrammed Cells Mediate the Development of Functional Organ

Direct reprogramming of fibroblasts using a thymus-specific transcription factor generates cell which mediate the formation of an entire organ upon transplantation in to a mouse model

Signalling Adapter Expression Boosts Induced Neuron Functionality

Researchers uncover a mechanism to boost the direct reprogramming of somatic cells to functional induced neural cells using a signaling adaptor protein.

Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells

Findings published on October 4th 2012 in Cell Stem Cell, have shown it is possible to reprogramme mouse and human pericytes, brain cells typically found surrounding the endothelial cells of the brain’s capillary network, into neurons. The results from Benedikt Berninger’s group at the Ludwig-Maximilians University Munich could have potential therapeutic implications for patients with traumatic and degenerative brain disorders.

Who Needs Pluripotency? - Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

From Cell Stem Cell
By Stuart P. Atkinson

Direct conversion of one somatic cell to another somatic cell type, completely bypassing the pluripotent stage through the forced expression of lineage specific transcription factors has emerged as a large “splinter group” of research, taking many lessons from induced pluripotent stem cell (iPSC) technology. The direct generation of induced neuronal cells (iN) from human fibroblasts has been previously demonstrated in several papers (Ambasuhan et al, Caiazzo et al, Pang et al, Pfisterer et al, Qiang et al, Son et al and Yoo et al.) however fibroblasts represent a heterogeneous mixture of cells, potentially including cells of the neural crest, and so the reprogrammed cell of origin remains undefined. Therefore, researchers from the group of Marius Wernig at the Stanford University School of Medicine, USA, decided to attempt to identify a specific somatic cell type from one germ lineage and reprogram these cells across the germ layer barrier into iN cells. The study, published as a short article in Cell Stem Cell demonstrates the direct conversion of mouse hepatocytes to iN cells and analyses the reprogramming process, demonstrating the faithful silencing of the hepatocyte expression program and the expression of the neuronal expression program (Marro et al).


Subscribe to RSS - Direct Reprogramming