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Cardiac Stem Cells

Predicting Cardiac Progenitor Cell Therapy Outcomes in the Failing Heart with miRNA Profiles

Researchers employ a computational modeling technique to establish a relationship between exosomal miRNA and responses in a rat myocardial infarction model

Electrical Stimulation of Pediatric CPCs

Cardiac‐derived progenitor cells (CPCs) have been widely studied as a cell‐based therapy for cardiac pathologies; however, they tend to display an age-related decline in therapeutic efficacy.

Discovery of Cardiac Progenitor Cell Proliferators

Small molecule activators of cardiac progenitor cell proliferation may form part of regenerative therapies for the treatment of myocardial infarction.

Extracellular Vesicles: The Driving Force Behind Cardiac Progenitor Cell Therapy

A study reports that extracellular vesicles from transplanted human cardiac progenitor cells drive the regenerative response following myocardial infarction

Predicting CPC Exosome Function with PLSR

Exosomes derived from cardiac progenitor cells (CPCs) can aid recovery from the severe right ventricular heart failure associated with congenital heart disease. In a recent STEM CELLS Translational Medicine study, researchers from the lab of Michael E.

Cell Therapy Outcome Prediction

A new STEM CELLS Translational Medicine study from the laboratory of Andre Terzic (Mayo Clinic, Rochester, Minnesota, USA) sought to understand outcome predictors when using stem cells to treat heart failure.

Epigenetic Priming - The Key to Effective Stem Cell Therapies for the Injured Heart?

Epigenetic priming of pluripotent stem cell-derived cardiac progenitor cells with polyinosinic‐polycytidylic acid results in mature cardiomyocyte production

Primed Cardiac Progenitors Accelerate Cardiomyocyte Maturation

Cardiomyocytes differentiated from human pluripotent stem cells (hPSC-CMs) tend to display an immature phenotype; however, a new study from the lab of Timothy J.

New Mapping Study in the Mouse Heart Finds No Evidence of Cardiac Stem Cells or Proliferative Cardiomyocytes

New results do not support the presence of quiescent cardiac stem cells, transdifferentiation into cardiomyocytes, or cardiomyocyte proliferation post-injury

Novel Reprogramming Approach for Cardiosphere-based Myocardial Regeneration

A new study in a myocardial infarction mouse model demonstrates how a novel reprogramming approach may permit enhanced cardiosphere-based myocardial regeneration

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