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What’s the Stem Cells Buzz this Week? - Stem Cell Signaling in Xenopus, ASCs and Corneal Failure, GABPα and mESC Survival, and Inhibiting Tumorigenicity with Reprogramming!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Delineating Stem Cell Signaling During Xenopus Intestinal Remodeling

Researchers from the lab of Atsuko Ishizuya-Oka (Nippon Medical School, Tokyo, Japan) recently sought to precisely understand control of adult epithelial development in the Xenopus laevis intestine by the canonical Wnt signaling pathway. Their recent STEM CELLS paper focused on the major Wnt target and thyroid hormone responsive gene CD44, demonstrating that TH activates hyaluronan/CD44 signaling in the metamorphosing intestine to control intestinal remodeling during adult stem cell development. It turns out that the amphibian intestine may be a highly valuable animal model for studies of stem cell regulation!

Adipose tissue-derived Mesenchymal Stem Cell Treatment for Corneal Failure

The loss or dysfunction of limbal stem cells can lead to visual loss, chronic pain, and inflammation of the ocular surface. The question arises; can we apply other adult stem cells to compensate for this loss? Researchers from the laboratory of Teresa Nieto-Miguel and Sara Galindo (Universidad de Valladolid, Spain) have recently demonstrated that transplantation of adipose tissue-derived mesenchymal stem cells (ASCs) into rabbit eyes lacking limbal stem cells was not only well tolerated, but also reduced inflammation and partially restored the corneal and limbal epithelial phenotypes. See STEM CELLS now for all the fine print.

GABPα and mESC Survival

The Ets-related transcription factor GA-binding protein alpha (GABPα) seemingly has its molecular toes in many a biological pie! To understand any potential role for GABPα in mouse embryonic stem cells (mESCs), the labs of Tadayuki Akagi and Takashi Yokota (Kanazawa University, Japan) generated and characterized a Gabpa conditional knockout ESC line. Overall, experiments employing these cells by Ueda et al. suggested that Gabpa normally functions to inhibit p53 accumulation and thereby regulates the proliferation and survival of ESCs. See STEM CELLS Translational Medicine for all the details.

Reprogramming inhibits Tumorigenicity!

Research from the labs of Chang-Shen Lin and Kazunari K. Yokoyama (Kaohsiung Medical University, Taiwan) sought to assess reprogramming of cancer cells to induced pluripotent stem cells (iPSCs) as a means of inhibiting oncogenesis. Their new STEM CELLS article now demonstrates that JDP2 and OCT4 can reprogram human gastric cells, and this process is associated with the epigenetic silencing of oncogenic BMP7 by the recruitment of HOXA13–HOTTIP and HOXA13–HOTAIR complexes. Sounds like an interesting study!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!