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What’s the Stem Cells Buzz this Week? - Smarca5 and HSCs, UCP2 and Embryonic Neurogenesis, Trialing CD34+ Cells for Cardiomyopathy, and Naming Endothelial Progenitors!



A roundup of some the recent stories in the ever-changing world of stem cells and regenerative medicine

HSPC Function Requires Smarca5

The conserved chromatin remodeler Smarca5 represents a molecular motor for DNA replication, repair, and transcription. The labs of Tomas Stopka (Charles University, Czech Republic) and Arthur I. Skoultchi (Albert Einstein College of Medicine, NY, USA) studied the hematopoietic system in response to Smarca5 loss and observed the accumulation of hematopoietic stem and progenitor cells (HSPCs) and the inhibition of maturation towards erythroid and myeloid lineages. This all suggests that Smarca5 is required for early hematopoiesis and erythropoiesis; head on over to STEM CELLS to discover all the details.

UCP2-mediated Regulation of Embryonic Neurogenesis

Recent research from the lab of Jian-Wei Jiao (Chinese Academy of Sciences, Beijing, China) sought to understand mitochondrial metabolism during embryonic neurogenesis. Their new Stem Cells study now demonstrates that the mitochondrial uncoupling protein 2 (UCP2) regulates embryonic neurogenesis by inhibiting reactive oxygen species (ROS) production. This increases the proliferation and decreases the differentiation of progenitors through a mechanism involving the ubiquitination of Yap transcriptional regulator. See all the details in STEM CELLS now!

Trialing CD34+ Cells for Nonischemic Dilated Cardiomyopathy

The lab of Bojan Vrtovec (Ljubljana University Medical Center, Slovenia) recently reported the results of a trial testing the effects of CD34+ cell transplantation on diastolic parameters in nonischemic dilated cardiomyopathy patients (DCM). The results, published in STEM CELLS Translational Medicine, suggest that “diastolic dysfunction is especially pronounced in patients with more myocardial scarring” and that “cell application appears to be associated with improvement in diastolic parameters”. Great news!

Naming Endothelial Progenitors: A Consensus Statement

Not a review or a research article; instead, the lab of Reinhold J. Medina (Queen's University Belfast, United Kingdom) have penned a consensus statement concerning the naming of endothelial progenitors. An expansion in the field necessitates this statement as “Ensuing confusion around endothelial progenitor cell -identity and function has sometimes diminished confidence in the field”. Medina et al hope that their article will “raise concerns on current standard practices and propose alternative, more accurate, terminology.” For all the fine print, see STEM CELLS Translational Medicine now!

So that’s a wrap for this week! Please let us know your views on all the stories we have covered here on the Stem Cells Buzz, and please let us know if we have missed anything interesting! Happy reading!