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What’s the Stem Cells Buzz this Week? - Retinal Stem Cell-Based Therapies, Bone Repair by SHEDs, Leukemia Stem Cells, and MSCs from Human Irradiated Skin!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Optimal Conditions for Retinal Stem Cell-Based Therapies

The transplantation of induced pluripotent stem cell (iPSC)-derived retinal progenitor cells (RPCs) represents an exciting strategy to treat degenerative retinal blindness, and a recent study from the lab of Elliott H. Sohn (University of Iowa, Iowa City, Iowa, USA) sought to evaluate the effect of commonly employed cell isolation and surgical manipulation strategies on donor cell viability. In a new STEM CELLS Translational Medicine article, Scruggs et al. suggest that needle cannula size, storage time, incubation temperature, and injection rate can influence cell viability and surgical outcomes following their research in Yucatan mini‐pigs.

FGF-2 Priming Enhances Bone Repair by Dental Pulp Stem Cells

Priming dental pulp stem cells from human exfoliated deciduous teeth (SHED) has been demonstrated to boost angiogenesis, and now, researchers from the lab of Caroline Gorin (Université Paris Descartes Sorbonne Paris Cité, France) sought to discover whether this strategy could improve bone formation by SHEDs in the context of craniofacial bone repair. Novais et al. report that FGF‐2 priming significantly enhanced SHED proliferation and osteogenic differentiation in plastically compressed collagen hydrogels and mediated faster intramembranous bone formation in critical size calvarial defects following implantation in immunodeficient mice. For all the fine print, see STEM CELLS Translational Medicine now!

Targeting Leukemia Stem Cells for Therapeutic Benefit

A recent article from researchers in the laboratories of Haojian Zhang (Wuhan University, Hubei, China) and Shaoguang Li (University of Massachusetts Medical School, Worcester, Massachusetts, USA) has discussed leukemia stem cells (LSCs) in human chronic myeloid leukemia (CML). The team focuses on the identification of unique biological features of these stem cells to emphasize the feasibility and significance of specific targeting of LSCs while sparing normal stem cell counterparts in leukemia therapy. For a great read, head over to STEM CELLS Translational Medicine now!

Ex Vivo Analysis of Mesenchymal Stem Cells from Human Irradiated Skin

A recent STEM CELLS Translational Medicine article from the lab of Alex K. Wong (Keck School of Medicine of USC, Los Angeles, California, USA) aimed to isolate and functionally characterize skin‐derived mesenchymal stromal cells (SMSCs) from human skin previously irradiated as part of neoadjuvant or adjuvant cancer therapy. Johnson et al. now report that in vivo radiotherapy of prompts diminished proliferation and differentiation of SMSCs and alters paracrine secretion, suggesting that ionizing radiation may contribute to chronic nonhealing wounds through these effects.

 

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!