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What’s the Stem Cells Buzz this Week? - MSCs at Fifty, Hematopoietic Stem Cell Fitness, Aging Effect of Pesticides on MSCs, and Chronic Wound Healing!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Mesenchymal Stem Cells at Fifty Years!

The ever-evolving and continuously expanding field of mesenchymal stem cell (MSC) research has seen a rise in clinical interest in recent years, with nearly 1,000 registered clinical trials. A recent review article from researchers led by Miroslaw Janowski (Johns Hopkins University School of Medicine, Baltimore, MD, USA) aims to commemorate the 50th anniversary of the first paper on MSCs from 1968 and discuss their therapeutic activities, including immunomodulation, trophic support, and differentiation in cell replacement strategies. For more, head over to STEM CELLS now!

p53-TIGAR Regulates Fanconi Anemia Hematopoietic Stem Cell Fitness

Researchers led by Wei Du (West Virginia University, West Virginia, USA) recently sought to explore the mechanisms responsible for energetic reprogramming in hematopoietic stem cells (HSCs) by studying the relationship between the predominant role of mitochondrial respiration compared to glycolysis in the maintenance of Fanconi anemia (FA) HSCs. Li et al. now report that an over‐activated p53‐TIGAR metabolic axis correlates to lower glycolysis in FA HSCs. Overall, p53‐TIGAR suppresses glycolysis in FA HSCs, leading to enhanced pentose phosphate pathway and cellular antioxidant function, and consequently reduced DNA damage and HSC exhaustion. Read more over at STEM CELLS!

Pesticides and Mesenchymal Stem Cell Aging

A recent study from the laboratories of Francois Vallette and Christophe Olivier (Université de Nantes, France) established that exposure to a low dose mixture of common pesticides induced oxidative stress‐related senescence and a differentiation propensity shift to adipogenesis in mesenchymal stem cells (MSCs). The team now return to report that the same pesticide mixture causes gene and protein expression indicative of an early aging phenotype that prompted the appearance of functional profile modification with similarities to the aging process. Head to STEM CELLS for all the details.

Dermal ABCB5+ Mesenchymal Stem Cells Promote Chronic Wound Healing

Recent research from the laboratory of Karin Scharffetter‐Kochanek (University of Ulm, Ulm, Germany) demonstrated that the ATP‐binding cassette protein ABCB5 marks a dermal cell subpopulation of the skin with multipotent mesenchymal stem cell (MSC) characteristics. The ABCB5+ MSCs maintained stemness and mesenchymal marker expression during long-term in vitro expansion as well as the ability for clonal self‐renewal and, importantly, these cells promoted healing of a non‐healing iron‐overload wound in a murine model. Overall, Vander Beken et al. believe that these ABCB5-positive MSCs may be exploited as a potential regenerative therapy for chronic venous leg ulcers in human patients. For all the fine print, see STEM CELLS now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!