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What’s the Stem Cells Buzz this Week? - MSC-Derived Exosomes, Repairing the BBB, MSCs and Multiple system atrophy, and Heart Development with PSCs!

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A roundup of some the recent stories in the ever-changing world of stem cells and regenerative medicine

Cell-Free Therapies: Reviewing MSC-Derived Exosomes

Mesenchymal stem cell (MSC)-based treatment strategies currently abound and some focus has shifted to MSC-derived exosomes as a safe and effective cell-free therapeutic option. In response, the labs of Donald G. Phinney and Mark F. Pittenger have sought to review “evidence that MSC-derived microvesicles/exosomes function as paracrine mediators in tissue repair and recapitulate to a large extent the therapeutic effects of parental MSCs.” See STEM CELLS now for a riveting read!

Repairing the BBB with hBMEPCs in Stroke Mice

The impairment of the blood-brain-barrier (BBB) represents a major problem related to ischemic stroke, although the labs of Svitlana Garbuzova-Davis and Cesario V. Borlongan (University of South Florida, USA) hope that human bone marrow endothelial progenitor cell (hBMEPC) transplantation may be an exciting therapeutic option. Their new STEM CELLS articles assessed this hypothesis in a rat stroke model and the team now suggest that mitochondrial preservation and augmented pinocytosis following hBMEPC transplant may represent a new neurorestorative mechanism in BBB repair for stroke.

Multiple system atrophy (MSA): Can MSCs Help?

The sporadic neurodegenerative disease multiple system atrophy (MSA) currently suffers from a lack of effective treatments. For this reason, the lab of Phil Hyu Lee (Yonsei University, Seoul, South Korea) sought to assess if the neuroprotective activity of mesenchymal stem cells (MSCs) may help MSA patients. Now, in a new STEM CELLS Translational Medicine study, Kim et al demonstrate that the intra-arterial administration of MSCs is feasible and efficient and leads to an improvement in neuronal viability and behavioral performance in a double toxin-induced MSA model.

 

Perspective: PSCs and Heart Development and Function in Health and Disease

A new perspective article from the lab Hananeh Fonoudi and Alexis Bosman provides us with a brief overview of current and potential uses of pluripotent stem cells (PSCs) in the investigation of early human heart development in both healthy and diseased states. Furthermore, the duo hopes to provide “guidance and insight into the complexities of establishing pluripotent stem cell models to probe early cardiogenesis and cardiovascular disease.” Get on over to STEM CELLS Translational Medicine for a fascinating read!

So that’s a wrap for this week! Please let us know your views on all the stories we have covered here on the Stem Cells Buzz, and please let us know if we have missed anything interesting! Happy reading!