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What’s the Stem Cells Buzz this Week? - iPSC Secretome, Stem Cell‐Derived Retina, Rejuvenating old HSCs, and Skeletal Muscle Stem Cells!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Klotho Mediates Protection by iPSC Secretome

Researchers from the lab of Connie C.W. Hsia (University of Texas Southwestern Medical Center, USA) recently assessed the anti-oxidant capacity of condition medium derived from induced pluripotent stem cells (iPSCs), which contains the cell's “secretome”. Gazdhar et al. now report both the importance of the α-Klotho protein in maintaining iPSC-mediated anti-oxidation and cytoprotection and also the potential for the iPSC secretome as a cell-free therapy for protection against lung injury. See STEM CELLS now for all the details.

In Silico Gene Sorting of Stem Cell‐Derived Retina

In an attempt to study single cells in the retina, researchers from the lab of David Gamm (University of Wisconsin-Madison, USA) have created and then analyzed optic vesicles generated from induced pluripotent stem cells (iPSCs) via standard single-cell RNA‐seq principle component analysis. Encouragingly, this allowed the authors of this exciting new study to deeply and rapidly examine retinal cell progeny and gene profile individual neural retina cell types. Head over to STEM CELLS now for all fine print!

Microvesicles from Young MSCs Rejuvenate Aged HSCs

Aging hematopoietic stem cells (HSCs) represent a significant problem for effective bone marrow transplantation; but, how can we avoid this unfortunate problem? Researchers from the lab of Vaijayanti P. Kale (National Centre for Cell Science, Maharashtra, India) now demonstrate that microvesicles from young mesenchymal stromal cells (MSCs) can rejuvenate aged HSCs via the transfer of autophagy-related mRNAs. Importantly, this new STEM CELLS study also demonstrates that rejuvenated HSCs display enhanced function in transplantation experiments; great news!

Delineating Notch-mediated Self-Renewal of Skeletal Muscle Stem Cells

While investigating the precise roles of Notch receptors in skeletal muscle stem cells, researchers from the laboratory of SiewHui Low (Carnegie Institution for Science, Baltimore, USA) have discovered that Notch3 regulates self-renewal. Their new study demonstrates that Dll4 in immature muscle fibers activates Notch3 on adjacent myoblasts to signal them to exit the cell cycle and return to mitotic quiescence, so ensuring the restoration in stem cell pool after repair-mediated activation. See STEM CELLS now for more of the exciting details!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!