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What’s the Stem Cells Buzz this Week? - How Cigarette Smoke affects ASCs, MSC-Cancer Cell Cross-talk, Stem Cell Defect in Transgenic Mice, and Gastric Cancer CSCs!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Cigarette Smoking Weakens ASC Therapeutic Activity

A new study from the labs of Keith L. March and Dmitry O. Traktuev (University of Florida, USA) aimed to discover how cigarette smoking affects the therapeutic activity of adipose stem cells (ASCs). Barwinska et al. determined that cigarette smoking decreases vasculogenic activity and limits the ability of ASCs to improve the recovery of ischemic tissue following systemic infusion. Furthermore, the authors linked this loss in therapeutically relevant functions to the loss of the angiostatic factor Activin A. For all the details, head over to STEM CELLS now!

Cross‐talk of Mesenchymal Stem Cells with Cancer Cells

Cross-talk between cancer cells and stem cells mediated by direct and indirect cellular interactions can lead to cell fusion and the creation of new cancer cell hybrids. A new Review article from the lab of Ralf Hass (Hannover Medical School, Germany) focuses on vesicle‐mediated indirect communication in cancer cell-mesenchymal stem cell (MSC) fusion. For more on this thought-provoking topic, make your way over to STEM CELLS now!

Stem Cell Defect in Transgenic Mice

Transplantation studies often employ transgenic mice line expressing the green fluorescent protein (GFP) under the direction of the human ubiquitin C promoter (UBC‐GFP mice). However, a new study from the laboratory of Emanuel Nečas (Charles University, Prague, Czech Republic) now provides evidence for a specific defect in the hematopoiesis of these model mice that compromises the lymphoid‐primed hematopoietic stem cells in the bone marrow and spleen. For more on this surprising finding, see STEM CELLS ASAP!

PGD2 Controls the Biological Behavior of Gastric Cancer CSCs

While many studies have demonstrated that prostaglandin D2 (PGD2) treatment has an anti-tumor effect on gastric cancer, the mechanisms at play remain shrouded in mystery. Now, researchers from the labs of Wenrong Xu and Hui Qian (Jiangsu University, Zhenjiang, China) report that signaling between PGD2 and its receptor (PTGDR2) restricts self‐renew of gastric cancer CSCs in vitro and suppresses tumorigenesis and metastasis in vivo via the inhibition of STAT3 phosphorylation and nuclear expression. Head over to STEM CELLS for all the fine print on this new study.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!