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What’s the Stem Cells Buzz this Week? - Compounding Factors, Muscle Stem Cells, Hemogenic Endothelium, and Endothelial Progenitor Cells!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Understanding Confounding Factors in Models of Human Erythropoiesis

Confounding factors, or intrinsic parameters within the experimental approach that bias the results, represent a significant problem for many models of healthy development and disease. While many early studies of the human erythropoiesis uncovered some simple confounding factors, each new and improved model highlights yet more! Now, a new review article from Anna Rita Migliaccio and Lilian Varricchio (Icahn School of Medicine at Mount Sinai, New York, USA) hopes to illustrate new confounding factors and discuss their clinical translation potential to improve our understanding erythroid disorders such as Diamond Blackfan Anemia. See STEM CELLS now for a riveting read!

Regulating Quiescent and Activated Muscle Stem Cells

A new study from the lab of Yusuke Ono (Nagasaki University Graduate School of Biomedical Sciences, Japan) studied roles for Notch1 and Notch2 expression in muscle stem cells. Fujimaki et al. report that Notch1 and Notch2 function together to maintain a quiescent stem-cell pool (by preventing activation) and to regulate stem-cell-fate decision in the activated state. For all the details on how Notch1 and 2 govern adult muscle regeneration, see STEM CELLS now.

Defining Transcriptional Signatures of the Hemogenic Endothelium

To characterize the mechanisms underlying human definitive hematopoietic development, researchers from the lab of Dan S. Kaufman (University of California-San Diego, USA) set out to study the endothelial-to-hematopoietic transition (EHT). Angelos et al. employed single cell RNA-seq of various cell types to demonstrate a common developmental pathway between human embryonic stem cell (hESC)-derived hemogenic endothelial cells and hematopoietic progenitor cells. The authors of this new STEM CELLS study hope to apply this strategy to test new genetic targets and optimize hematopoietic development from hESCs.

Regulating Endothelial Progenitor Cells with HAX-1

Precious studies had linked expression of Hematopoietic-substrate-1 associated protein X-1 (HAX-1) to tumorigenesis; however, researchers from the lab of Xin-bin Guo (First Affiliated Hospital of Zhengzhou University, China) explored a role for HAX-1 expression in endothelial progenitor cells (EPCs). Their new STEM CELLS study now suggests that the high levels of HAX-1 expression noted in EPCs promotes proliferation and inhibits apoptosis via a decline in p53 tumor suppressor levels.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!