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What’s the Stem Cells Buzz this Week? - Chromosome Transplantation, Anti-Osteoporosis Effect of Bmi1, HSC Dynamics, and Spinal Cord Injury Treatment!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Chronic Granulomatous Disease Correction by Chromosome Transplantation

As current gene-editing strategies cannot reverse disease-associated structural chromosome abnormalities, researchers from the lab of Marianna Paulis (Italy and Humanitas Clinical and Research Center, Rozzano, Italy) devised a chromosomal transplantation (CT) approach as a means to replace an endogenous mutated chromosome with an exogenous normal one. Their recent STEM CELLS article establishes proof of principle for CT in induced pluripotent stem cells derived from a patient with chronic granulomatous disease. Encouragingly, Castelli et al. demonstrated that X‐chromosome transplanted corrected cells restored the normal function to differentiated cells in what represents an important step towards the application of this kind of genomic therapy in selected patients.

Bmi1 in Mesenchymal Stem Cells Exerts an Anti-Osteoporosis Effect

The lab of Dengshun Miao (Nanjing Medical University, Nanjing, China) previously reported that Bmi1 deficiency promoted osteoporosis by inhibiting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs). They now return with a new STEM CELLS paper to understand whether MSCs overexpressing Bmi1 stimulate skeletal development and rescue Bmi1 deficiency‐induced osteoporosis. Chen et al. established that MSCs overexpressing Bmi1 exert an anti‐aging and anti‐osteoporosis effect in a study that may provide a means to enhance the functionality of MSCs for therapeutic applications.

Studying Hematopoietic Stem Cell Dynamics During Aging

Researchers from the lab of Ingmar Glauche (Technische Universität Dresden, Germany) sought to understand the effect of normal aging on hematopoiesis through a novel in‐silico model to investigate the dynamics of hematopoietic stem cell (HSC) response to varying demand. In their recent article, Klose et al. focused on the HSCs that can reconstitute the whole blood system after injury and by investigating cellular mechanisms that are altered upon aging, the authors reveal potential targets to be tackled for sustaining a healthy lifespan. For all the details on this intriguing study, head over to STEM CELLS.

The Potential of Induced Pluripotent Stem Cells for Spinal Cord Injury Treatments

Researchers from the lab of Luis G. Villa‐Diaz (Oakland University, Rochester, Michigan, USA) recently undertook a review and meta‐analysis to evaluate the efficacy of applying induced pluripotent stem cells (iPSCs)‐derived neural cells to restore motor function in experimental animal models of traumatic spinal cord injuries. Ramatowski et al. also addressed current concerns with the use of iPSC‐derived neural cells and asked whether this provides similar results as treatment with cells derived from embryonic stem cells, which have already been successfully employed to treat injuries to the central nervous system. For a great read, head over to STEM CELLS Translational Medicine.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!