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What’s the Stem Cells Buzz this Week? - CAMKK1 and Cardiac Repair, Stem Cell Educator Therapy, Engineered Biosphincters, and Mapping Megakaryocytes!

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A roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond brought to you by the Stem Cells Portal!

CAMKK1 Improves MSC-mediated Cardiac Repair

Factors secreted by mesenchymal stem cells (MSCs) hold great promise in the treatment of many diseases and disorders, including ischemic cardiomyopathy. Recent work from the lab of Maritza E. Mayorga (Northeast Ohio Medical University, USA) sought to discover MSC-secreted factors that improve cardiac function following the downregulation of the Dab2 TGFβ1 receptor adaptor protein. The lab’s new STEM CELLS Translational Medicine article suggests that the protein kinase calcium/calmodulin-dependent protein kinase kinase-1 (CAMKK1) protein is of fundamental importance.

 

Stem Cell Educator Therapy for Diabetes: 4-year follow-up

Stem cell educator (SCE) therapy for diabetes relies on treatment with autologous blood immune cells exposed to cord blood stem cells. The lab of Yong Zhao (Hackensack University Medical Center, New Jersey, USA) has recently reported on their 4-year follow-up studies in STEM CELLS Translational Medicine in type 1 and type 2 diabetic patients. Zhao et al. now suggest that SCE therapy is safe and effective and functions by altering the mitochondria released by platelets, which displayed immune tolerance-, embryonic stem cell-, and islet β-cell-associated markers, leading to the improvement of islet β-cell functions.

 

Engineered Biosphincters for Passive Fecal Incontinence

A recent study from the lab of Khalil N. Bitar (Wake Forest Institute for Regenerative Medicine, Winston-Salem, USA) has assessed engineered autologous internal anal sphincter (IAS) biosphincters for the treatment of passive fecal incontinence in a rabbit model. Encouragingly, their new STEM CELLS Translational Medicine study now suggests that this strategy is safe and effective and Bohl et al. hope to explore a human-centric strategy with patient's cells to engineer a new sphincter to help restore continence.

Mapping the Path taken from HSPCs to Megakaryocytes

A new review article from the lab of Hidekazu Nishikii (University of Tsukuba, Japan) has summarized recent findings related to megakaryocytes differentiation from hematopoietic stem cells (HSCs) in the hope of creating a map of the route taken! Furthermore, this new STEM CELLS Translational Medicine hopes to discuss the potential future directions in this exciting research area. Sounds like a great read!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!