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What’s the Stem Cells Buzz this Week? – TEC and hPSCs, Hemodynamic Vascular Cell induction, Ex vivo-generated Erythrocytes, and MSC Treatment for Felines!



A roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond brought to you by the Stem Cells Portal

TEC- and FGF2-mediated Control of Human Pluripotent Stem Cells

A recent study from the labs of Petr Dvořák and Michaela Bosáková (Masaryk University, Brno, Czech Republic) has described the role of the TEC kinase (tyrosine kinase expressed in hepatocellular carcinoma) in human pluripotent stem cell (hPSC) self-renewal and differentiation. Vanova et al. describe how TEC mediates FGF2 secretion to boost hPSC self-renewal, while a lack of TEC promotes differentiation into the neuroectodermal lineage and inhibits the development of cardiac mesoderm. See STEM CELLS now for all the fine print!

Hemodynamic Exposure Induces Vascular Cell Phenotypes

Vascular endothelial (iECs) and smooth muscle cells (iSMCs) derived from induced pluripotent stem cells (iPSCs) often display signs of immaturity, making them less suitable for therapeutic application. To counteract this lack of adequate development, the lab of Brian R. Wamhoff (HemoShear Therapeutics, LLC, Charlottesville, Virginia, USA) asked whether hemodynamic exposure could help to mature iECs and iSMCs. In their new STEM CELLS Translational Medicine study, the team now demonstrate that hemodynamic exposure facilitated the maturation of iPSC-derived cells and permitted a high degree of similarity to primary cells in their responses to pathological stimuli associated with vascular diseases.

Ex vivo-generated Erythrocytes from Cord Blood – The Blood Source of the Future?

The ex vivo generation of red blood cells (or erythrocytes) from various cellular sources may represent an exciting means to generate large amounts of blood for transfusion purposes. The lab of Yongping Jiang (Chinese Academy of Medical Sciences & Peking Union Medical College) recently assessed erythrocyte production from cord blood (CB) CD34+ cells employing a bottle turning device culture system. Their new STEM CELLS Translational Medicine study suggests that 5 million CD34+ cells may produce enough erythrocytes for 500 blood transfusion units, while xenotransfusion studies in non-human primates with hemorrhagic anemia confirmed the safety and efficiency of this approach!


MSC Treatment for Feline Oral Mucosal Inflammatory Disease

While the immunomodulatory functions of mesenchymal stem cells (MSCs) have made them an exciting treatment options for immune-mediated inflammatory disorders in humans, the team of Boaz Arzi (UC Davis, USA) also hope to apply these useful cells in our furry feline friends! In detail, Arzi et al. assessed the ability of fresh allogeneic adipose-derived MSCs (ASCs) to treat the chronic oral mucosal inflammatory disease feline chronic gingivostomatitis (FCGS). For all the details on their successful findings, head over to STEM CELLS Translational Medicine now.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!