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What’s the Stem Cells Buzz this Week? – Modeling Glaucoma, Accelerating Fracture Healing, Treating Lung Disease, and a Lung Disease Workshop Report!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Modeling Glaucoma with Mutant iPSCs

To assess the contribution of progressive retinal ganglion cell (RGC) degeneration to glaucoma, researchers from the lab of Iqbal Ahmad (University of Nebraska Medical Center, USA) have modeled the disease via the generation and RGC-specific differentiation of induced pluripotent stem cells (iPSCs) carrying a glaucoma risk allele. Teotia et al. now demonstrate that SIX6 mutations influence RGC differentiation and their survival and so may make RGCs vulnerable in glaucoma in the adult. Head over to STEM CELLS now for all the details.

Accelerating Fracture Healing with Engineered MSCs

To accelerate bone fracture healing via the reparative/regenerative actions of mesenchymal stem cells (MSCs), researchers from the lab of Wei Yao (UC Davis, California, USA) have engineered cells to overexpress basic fibroblast growth factor (bFGF). Excitingly, their strategy accelerated fracture healing by increasing the production of growth factors that both stimulated angiogenesis and enhanced the differentiation of MSCs to osteoblasts that formed new bone. See all the exciting details at STEM CELLS Translational Medicine.

Treating Lung Disease with Allogeneic Lung Spheroid Cells

Cell therapy employing adipose or bone marrow-derived mesenchymal stem cells (MSCs) represents a promising treatment strategy for pulmonary fibrosis. However, new research from the labs of Ke Cheng and Leonard Jason Lobo (University of North Carolina, USA) took another path and assessed the utility of adult lung spheroid cells (LSCs) as an intrinsic source of therapeutic lung stem cells. Encouragingly, Cores et al. report that the infusion of allogeneic LSCs reduced progression of inflammation and fibrotic manifestation and preserved epithelial and endothelial health without eliciting a significant immune rejection. Read all the fine print over at STEM CELLS Translational Medicine.

Proceedings from the CIRM Regenerative Medicine for Lung Diseases Workshop

In a recent article, Lisa C. Kadyk, Natalie D. DeWitt, and Brigitte Gomperts have reported on the 2016 California Institute of Regenerative Medicine (CIRM) workshop on regenerative medicine approaches for the treatment of lung diseases. To read about all that went on at this highly engaging workshop, see STEM CELLS Translational Medicine now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!