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What’s the Stem Cells Buzz this Week? – Inflammatory Cycling in MSCs, Slimming-down MSCs with Vesicles, Boosting Bone and Cartilage Regeneration, and Trialing Autologous Cord Blood!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

MSCs-EVs Caught in an Inflammatory Cycle

A new study by the lab of Matthew T. Harting (University of Texas McGovern Medical School, USA) has suggested that mesenchymal stem cells (MSCs) and secreted extracellular vesicles (EVs) may be caught in an inflammatory cycle! Specifically, their new STEM CELLS study demonstrates that inflammatory stimulation of MSCs results in the release of EVs with enhanced anti-inflammatory effects, attributed in part to COX2/PGE2 expression. Could this new report lead to the construction of EV therapeutic strategies for inflammatory injury and disease?

Vesicles Help 3D MSCs Slim Down

Vesicles also play a significant role in our next study from the laboratory of Yaojiong Wu (Tsinghua University, China). Their new STEM CELLS study sought to delineate the mechanisms behind mesenchymal stem cell (MSC) size reduction under three-dimensional (3D) culture conditions. A decrease in MSC size, as compared to typical two-dimensional culture, reduces lung vascular obstructions following MSC therapy and this new study suggests that MSCs “slim down” by increasing vesicle excretion mediated by lowering cytoskeleton tension. Sounds like a great read!

Boosting Cartilage and Bone Regeneration: A Review

A new review article from researchers from the laboratory of Ennio Tasciotti (Houston Methodist Research Institute, Texas, USA) aims to highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. This review maintains a focus on strategies likely to be efficiently translated into clinical practice and reflects on contemporary and cutting-edge regenerative approaches in surgery. While studies have highlighted a range of preclinical solutions for bone and cartilage regeneration, only a few platforms have been able to move from the bench to the bedside. See STEM CELLS Translational Medicine now for a timely review article!

Trialing Autologous Cord Blood Infusion in Young Cerebral Palsy Patients

STEM CELLS Translational Medicine brings us the results of a recent trial carried out by the laboratory of Jessica Sun (Duke University Medical Center, California, USA). The authors describe a Phase II trial of autologous cord blood (ACB) infusions in children with Cerebral palsy (CP) to test whether this approach could improve motor functions (ClinicalTrials.gov, NCT01147653; IND 14360). In brief, the results demonstrate that appropriately dosed ACB infusions have the potential to improve brain connectivity and gross motor function in young children with CP. Encouraging news!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!