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What’s the Stem Cells Buzz this Week? – Chemoresistance in CSCs, MSC-IL6 and CSC Formation, Exosomal ncRNA Showdown in PSC-CMs, and the Therapeutic How-to Guide for EVs!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

CSCs Acquire Chemoresistance through FBXW7 and c-Myc

Using a previously established colorectal cancer stem cell model, the team of Takatsugu Ishimoto (Kumamoto University, Japan) has recently identified a potential means to inhibit CSC-mediated resistance to anticancer agents. Their new STEM CELLS study indicates that overexpression of FBXW7 in CSCs mediates the loss of c-Myc expression and reduces sensitivity to anticancer agents. Therefore, Izumi et al. suggest that “inhibition of FBXW7-upregulation in CSCs after chemotherapy may enhance response to anticancer agents and may be an effective strategy to eliminate colorectal CSCs.”

MSC-IL6 Promotes CSC-like Transformation through EMT

A new study from the labs of Anh D. Le and Qunzhou Zhang (University of Pennsylvania, USA) has investigated cancer stem cell (CSC)-like transformation in benign epithelial tumors, specifically solid/multicystic follicular ameloblastoma (AM). Jiang et al. now demonstrate that Interleukin-6 (IL6) secreted from mesenchymal stem cells (MSCs) promotes a CSC-like transformation by inducing an epithelial-mesenchymal transition (EMT) in epithelial cells via STAT3 and ERK1/2-mediated signaling pathways. See STEM CELLS now for all the details.

ESC-CMs vs. iPSC-CMs: The Exosome ncRNA Showdown for MI

The labs of Joseph C. Wu or Sang-Ging Ong (Stanford University School of Medicine, CA, United States) bring a scientific showdown to STEM CELLS in the form of a comparison human embryonic stem cell-derived cardiomyocytes (ESC-CMs) and human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for cardiac regenerative therapy. Lee et al. report that an identical repertoire of microRNAs and long non-coding RNAs play a role in improved cardiac function following iPSC- and ESC-CM transplantation. For all the details, see STEM CELLS now!

Extracellular Vesicles: The How-To Guide for Therapeutic Use

A report published recently in STEM CELLS Translational Medicine reads like a veritable “How-to Guide” for the therapeutic use of extracellular vesicles (EVs). This new article provides details on the recent workshop convened by the members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles (Singapore) to discuss opportunities/challenges associated with the development of EV-based therapeutics at both preclinical and clinical levels. Head on over to this article from Eva Rohde (Paracelsus Medical University, Salzburg, Austria) and Sai Kiang Lim (A*STAR, Singapore) to see how the Workshop’s suggestions may enhance the development of best-practice models for EV therapies now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!