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USSCs Improves Neurobehavioral Performance

Intraventricular hemorrhage (IVH), a severe complication of preterm birth leading to hydrocephalus, cerebral palsy, and mental retardation, suffers from a lack of therapeutic approaches. However, researchers led by Govindaiah Vinukonda (New York Medical College, Valhalla, New York, USA) recently demonstrated that unrestricted somatic stem cells (USSCs) from human cord blood administered to preterm rabbits with IVH leads to decreased microglial infiltration, pro‐inflammatory cytokine expression, and apoptotic cell loss. Encouragingly, this approach led to a partial recovery of myelination, preservation of white matter, and resumption of motor function, thereby supporting the application of cord blood‐derived stem cells for the treatment of degenerative processes caused by IVH. For more, see STEM CELLS Translational Medicine.