You are here

SPARC Promotes Limbal Stem Cell Proliferation

In a recent STEM CELLS article, researchers led by Jing Zhou (Shandong University, Shandong, China) confirmed that secreted protein acidic and rich in cysteine (SPARC) had the ability to promote the proliferation and suppress the spontaneous differentiation of limbal epithelial stem cells (LESCs) in vitro through the JNK/p38 MAPK signaling pathway. The authors also revealed that exogenous SPARC accelerated corneal epithelial wound healing and promoted the proliferation of p63-alpha‐positive cells both in the limbus and epithelial healing front in a corneal wound model. Overall, these new findings suggest SPARC as a potential agent to cure LESC deficiency‐related diseases and as a potential supplement to aid the expansion of LESCs for corneal regenerative medicine approaches.