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SIRT1 Promotes Beta-cell Regeneration

As calorie restriction can induce β cell regeneration, researchers led by Po Sing Leung (Chinese University of Hong Kong, Shatin, New Territories, Hong Kong) recently evaluated a role for sirtuin 1 (SIRT1), a calorie restriction mimic, in the stimulation of β‐cell regeneration. Writing in STEM CELLS, Wu et al. demonstrate that SIRT1 activation promotes β‐cell regeneration via the enhanced activation of endocrine progenitors and the promotion of endocrine progenitor differentiation via a mechanism that involves AMPK signaling‐regulated fatty acid oxidation. The authors hope that their findings will promote the development of new strategies for β‐cell restoration as well as for β‐cell production for islet transplantation in patients with diabetes.