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Roles of SMYD2 in Mesendoderm Commitment of hESCs

A recent article from the laboratory of Huang‐Tian Yang (University of Chinese Academy of Sciences, Shanghai, China) explored the role of the SMYD2 (SET and MYND domain‐containing protein 2) histone lysine methyltransferase in the self‐renewal and mesendodermal lineage commitment of human embryonic stem cells (hESCs). Bai et al. now report that SMYD2 is dispensable for hESCs in the undifferentiated state and early neuroectodermal differentiation; however, SMYD2 promotes the mesendodermal differentiation of hESCs through the epigenetic control of critical genes to mesendodermal lineage commitment. For all the fine print, see STEM CELLS now!