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Proteasome Activation Mediates Exercise-Elicited Hippocampal Neurogenesis

A new study from the laboratories of Wulin Yang (Chinese Academy of Sciences, Hefei, China) and Li Lu (Shanxi University, Taiyuan, China) recently demonstrated that voluntary exercise causes hippocampal proteasome activation and the improved activity of adult neural progenitor cells.  Niu et al. discovered that exercise induces the increase of insulin-like growth factor 1 (IGF‐1) in serum and hippocampus, which triggers the nuclear translocation of nuclear factor erythroid 2‐related factor 2 (Nrf2) to promote the expression of the critical proteasome subunit PSMB5 to enhance adult neurogenesis. Overall, the findings of this STEM CELLS study reveal novel insights into the modulation of adult neurogenesis through proteasome activation via the IGF‐1/Nrf2 signaling pathway.