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Phospho-STAT Assay Matrix Determine Mesenchymal Stem Cell Potency

Advanced clinical trials will require the definition of the immune potency of mesenchymal stem cell (MSCs) destined to be administered to human patients and to this end, researchers from the laboratories of Raghavan Chinnadurai and Jacques Galipeau (University of Wisconsin‐Madison, Wisconsin, USA) have developed a loop analytical phosphomatrix approach. The authors developed an assay matrix approach that captures the STAT phosphorylation profile of MSCs upon stimulation with their combined secretome that arises with the interaction of activated peripheral blood mononuclear cells. For more details on assay development and the results, see STEM CELLS now!