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Organoids and Retinal Diseases: A Review

Three-dimensional retinal organoids display enormous potential for the investigation of the pathogenesis of monogenic hereditary eye diseases related to the malfunction or degeneration of photoreceptors or retinal ganglion cells (RGCs) by providing an amenable in vitro tool with multiple applications. Moreover, three-dimensional retinal organoids combined with genome editing technologies may represent a means to generate a reliable and renewable source of transplantable cells for personalized therapies. Now, a STEM CELLS review article from the lab of Slaven Erceg (CIPF, Valencia, Spain) discusses recent advances in pluripotent stem cell (PSC)‐derived retinal organoids and discuss their application as a means to decipher the pathogenesis of retinal diseases.