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Nucleoskeletal Regulation of MSC Differentiation

Nuclear morphology contributes to chromatin organization and gene expression, and now, researchers from the laboratory of Janet Rubin (University of North Carolina at Chapel Hill, North Carolina, USA) suggest that nuclear-localized formin Diaph3 (mDia2) alters nuclear actin dynamics and nucleoskeletal lamin integrity and may serve as a means to investigate nuclear actin morphology without grossly affecting cytoplasmic actin structure. In their STEM CELLS study, Sankaran et al. discovered that silencing mDia2 disrupted the actin‐lamin nucleoskeleton and altered nuclear morphology, thereby causing the release of mesenchymal stem cells (MSCs) from their stem state and promoting differentiation. Overall, the authors propose that the structural arrangement of the nucleoskeleton plays a crucial role in stem cell lineage commitment.