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Non‐Wnt ligand Norrin Activates Hair Follicular Growth

A recent STEM CELLS study from the laboratory of Daniel Aberdam (Université de Paris, Brive, France) sought to understand the contribution of extracellular vesicles isolated from stimulated human dermal fibroblasts on dermal papilla cells activation and hair follicle growth. le Riche et al. now report that dermal papilla cells treated with extracellular vesicles secrete Norrin, a non‐Wnt ligand that activates the β‐catenin pathway of recipient human hair follicular keratinocytes, to enhance hair follicle growth ex vivo.

Also see the Press Release from the Stem Cells Portal “Study Reveals How Protein Norrin Helps Activate Hair Growth” (