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MSC-Secreted HGF Modulates Corneal Alloimmunity

Researchers led by Sunil K. Chauhan (Harvard Medical School, Boston, Massachusetts, USA) recently sought to understand how mesenchymal stem cells (MSCs) promote allograft survival in a mouse model of corneal transplantation. Their new STEM CELLS Translational Medicine article now reveals that the secretion of the pleiotropic molecule hepatocyte growth factor (HGF) by MSCs suppresses the allogeneic immune response, thereby promoting transplant survival. Mittal et al. hope that these encouraging findings will aid in the development of HGF‐based therapeutics to enhance transplant outcomes in a range of tissues.